基于“久病血瘀,瘀毒损络”病机下慢传输型便秘临床研究

Clinical Research of Slow Transit Constipation based on “Chronic Blood Stasis and Venation Damage”

目的:探讨基于"久病血瘀、瘀毒损络"病机下化瘀通便汤治疗慢传输型便秘的临床研究效果。方法:选取2016年12月—2018年2月我院收治的80例慢传输型便秘患者,根据随机数字表法分为对照组与治疗组,每组40例。对照组予以麻仁润肠丸,治疗组应用化瘀通便汤,两组患者均治疗2周。比较两组患者临床疗效、血清相关胃肠激素表达水平、排便症状评分及中医证候积分情况。结果:经治疗,治疗组临床总有效率为95.00%,对照组临床总有效率为87.50%,说明治疗组方案优于对照组,差异具有统计学意义(P<0.05);经治疗,两组患者血清相关胃肠激素表达水平均有所改善,其中治疗组患者P物质(SP)升高较对照组显著(P<0.05),血管活性肠肽(VIP)、水通道蛋白1、水通道蛋白3及神经肽Y(NPY)降低亦较对照组显著(P<0.05);与对照组相比较,治疗组患者排便症状评分改善更为明显,差异具有统计学意义(P<0.05);治疗后,治疗组患者中医症状积分显著低于对照组,说明治疗组方案在中医疗效方面较对照组更具优势,差异具有统计学意义(P<0.05)。结论:化瘀通便汤针对慢传输型便秘的治疗取得较好的临床疗效,可起到活血化瘀、解毒通络的作用,促进血清相关物质表达水平趋于正常,值得临床推广应用。

Objective:To discuss the effect of slow transit constipation based on"chronic blood stasis and venation damage"in clinical research. Methods:80 patients with slow transit constipation who were treated in our hospital from December 2016 to February 2018 were selected and divided into a control group and a treatment group according to the random number table method,40 cases each group. The control group was treated with Maren Runchang Pills and the treatment group was treated with Huayu Tongbian Decoction.Both groups were treated for 2 weeks. The clinical efficacy,serum-related gastrointestinal hormone expression levels,defecation symptom scores and traditional Chinese medical syndrome scores were compared between the two groups. Results:After treatment,the total effective rate in the treatment group was95.00%,while the total effective rate in the control group was 87.50%,which indicated that the treatment group scheme was better than the control group,and there was a statistics significance difference between the two groups(P<0.05);At the same time,the serum levels of gastrointestinal hormones were improved in the patients,with a significant increase in substance P(SP)in the treatment group compared with the control group(P<0.05),the decrease of vasoactive intestinal peptide(VIP),aquaporin 1,aquaporin 3 and neuropeptide Y(NPY)were also significantly higher than that in the control group(P<0.05). The scores of defecation symptoms improved more significantly in the treatment group comapred with the control group(P<0.05);After treatment,the scores of TCM symptoms in the treatment group were significantly lower than those in the control group,which showed that the treatment group program was effective in Chinese medicine. Compared with the control group,it had more advantages,and the difference was statistically significant(P<0.05). Conclusion:Huayu Tongbian Decoction can achieve good clinical curative effect in slow transit constipation. It can play a role in activating blood and removing stasis and removing toxic and clean venation,collaterals promoting the expression of serum related substances to normal,which means it own worth in clinical application.