三维适形放疗同步替吉奥化疗治疗Ⅱ～Ⅲ期食管癌的临床疗效及预后分析

Analysis on Clinical Curative Effect and Prognosis of Three-Dimensional Conformal Radiotherapy Combined with Tiggio Chemotherapy in the Treatment of Stage Ⅱ to Ⅲ Esophageal Cancer

目的探讨三维适形放疗同步替吉奥化疗治疗Ⅱ～Ⅲ期食管癌的临床疗效及预后情况。方法选取我院2013年6月至2015年6月收治的Ⅱ～Ⅲ期食管癌患者80例,分为对照组和观察组各40例,两组患者均采用三维适形放疗,观察组在放疗期间同步口服替吉奥胶囊治疗。对比两组的临床疗效,并对患者进行随访,观察两组的1年和3年生存率,统计不良反应发生率。结果观察组的RR为82.50%,明显高于对照组的60.00%(P <0.05)。观察组的1年和3年生存率均明显高于对照组(P <0.05)。两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论三维适形放疗同步替吉奥化疗治疗Ⅱ～Ⅲ期食管癌患者的临床疗效显著,可有效改善患者的生存情况。

Objective To explore the clinical curative effect and prognosis of three-dimensional conformal radiotherapy combined with Tiggio chemotherapy in the treatment of stage Ⅱ to Ⅲ esophageal cancer. Methods 80 cases of patients with stage Ⅱ to Ⅲ esophageal cancer admitted to our hospital from June 2013 to June 2015 were selected and divided into control group and observation group, with 40 cases in each group. Both groups received three-dimensional conformal radiotherapy. The observation group was treated with simultaneous oral Tiggio capsules during radiotherapy. The clinical curative effect of the two groups was compared. After followed-up, the 1-year and3-year survival rates of the two groups were observed. The incidence of adverse reactions was recorded. Results The RR of the observation group was 82.50%, significantly higher than 60.00% of the control group(P<0.05). The 1-year and 3-year survival rates of the observation group were significantly higher than those of the control group(P<0.05). No statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05). Conclusions Three-dimensional conformal radiotherapy combined with Tiggio chemotherapy in the treatment of patients with stage Ⅱ to Ⅲ esophageal cancer has significant clinical curative effect, which can effectively improve the survival of patients.