FH检测试剂盒在宫颈癌筛查中的应用价值

Clinical Value of FH Detection Kit in Cervical Cancer Screening

目的:探讨宫颈微环境中细胞游离亚铁原卟啉(FH)试剂盒在宫颈癌筛查上的应用价值。方法:抽取进行宫颈癌筛查的女性人群及门诊就诊的女性患者共561例,进行FH检测。以活检病理检查结果作诊断的金标准,计算FH检测在宫颈癌筛查中的灵敏度、特异度、准确度。结果:FH检测宫颈病变≥CIN1的灵敏度为58.49%,特异度为70.15%,阳性预测值为43.66%,阴性预测值为81.03%,准确度为66.84%;FH检测宫颈病变≥CIN2的灵敏度为63.43%,特异度为70.02%,阳性预测值为39.91%,阴性预测值为85.92%,准确度为68.45%。FH检测对宫颈病变≥CIN1和宫颈病变≥CIN2的诊断能力与病理结果比较均具有统计学意义(P<0.05)。结论:FH检测方法方便快捷,在经济发达地区宫颈癌初筛中有重要的应用价值。

Objective:To explore the clinical value of cell free ferrous protoporphyrin(FH) detection kit in cervical microenvironment for the screening of cervical carcinoma. Methods: A total of 561 women and outpatients who underwent cervical cancer screening at the Peace Hospitial,Heji Hospital Affiliated to Changzhi Medical College and Changzhi People's Hospital were selected fo FH testing. Taking pathological examination results as the gold standard for diagnosis,the clinical application value of FH kit in cervical cancer screening was investigated by calculating the sensitivity,specificity and accuracy. Results: The difference between the FH test results of 56l subjects and the pathological results of cervical lesions was statistically significant(Z=7.011,P<0.05).The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of FH detection of lesion CIN1 were 58.49%,70.15%,43.66%,81.03% and 66.84%,respectively. The sensitivity,specificity,positive predictive value and negative predictive value were 63.43%,70.02%,39.91%,85.92% and 68.45% respectively. Conclusion: FH testing has certain clinical value for cervical cancer screening in areas where health resources are scarce in China.