米非司酮联合甲氨蝶呤治疗输卵管妊娠148例的临床效果分析

Clinical effect of mifepristone combined with methotrexate in the treatment of 148 cases of tubal pregnancy

目的:探讨米非司酮联合甲氨蝶呤对异位妊娠的治疗效果。方法:收治输卵管妊娠保守治疗患者148例,随机选择米非司酮联合甲氨蝶呤与单独甲氨蝶呤治疗。对比两种方法的治疗效果及不良反应。结果:治疗后,两组患者的β-HCG水平、异位妊娠包块直径均显著降低(减小),联合治疗组的β-HCG、异位妊娠包块直径在治疗7、10、14 d复查指标均优于单独组,差异有统计学意义(P<0.05);两组保守治疗失败的患者均转手术治疗。联合治疗组血β-HCG值完全恢复正常时间、异位妊娠包块消失时间均显著低于单独组,差异有统计学意义(P<0.05)。结论:米非司酮联合甲氨蝶呤治疗宫外孕疗效显著,安全性高。

Objective:To explore the therapeutic effect of mifepristone combined with methotrexate in the treatment of ectopic pregnancy.Methods:148 patients with conservative treatment of tubal pregnancy were selected,they were treated with mifepristone combined with methotrexate and methotrexate alone.The therapeutic effects and adverse reactions of the two methods were compared.Results:After treatment,the level of β-HCG and the diameter of ectopic pregnancy mass in the two groups were significantly decreased.The indexes of β-HCG and the diameter of ectopic pregnancy mass in the combined treatment group were lower than those in the single group on the 7th,10th and 14th day after treatment,the differences were statistically significant(P<0.05).Both groups of patients who failed conservative treatment were transferred to surgery.The time of blood β-HCG returning to normal and the time of ectopic pregnancy mass disappearing in the combined treatment group were significantly lower than those in the single group,and the difference was statistically significant(P<0.05).Conclusion:Mifepristone combined with methotrexate is effective and safe in the treatment of ectopic pregnancy.