温针灸联合骨康胶囊治疗原发性骨质疏松症的疗效及对骨代谢指标的影响

Efficacy of Warm Needling Moxibustion plus Gukang Capsules for Primary Osteoporosis and Its Effect on Bone Metabolism Indicators in the Patients

目的观察温针灸联合骨康胶囊治疗原发性骨质疏松症的疗效及对患者骨代谢水平的影响。方法选取原发性骨质疏松症患者109例,按照随机数字表法分为观察组56例和对照组53例。对照组采用温针灸治疗,观察组在对照组基础上结合骨康胶囊治疗。两组疗程均为12周。比较两组疗效,治疗前后骨密度、骨代谢、VAS评分和Oswestry功能障碍指数评分变化。结果观察组总有效率(94.6%)高于对照组(71.7%)(P<0.05)。两组治疗后腰椎和股骨颈骨密度均增加(P<0.05);观察组治疗后腰椎和股骨颈骨密度高于对照组(P<0.05)。两组治疗后骨特异性碱性磷酸酶(B-ALP)和Ⅰ型前胶原N端前肽(PINP)水平降低(P<0.05);观察组治疗后B-ALP和PINP水平低于对照组(P<0.05)。两组治疗后VAS评分和Oswestry功能障碍指数评分降低(P<0.05);观察组治疗后VAS评分和Oswestry功能障碍指数评分低于对照组(P<0.05)。结论温针灸联合骨康胶囊治疗原发性骨质疏松症患者疗效明显,且可改善患者骨代谢。

Objective To investigate the efficacy of warm needling moxibustion plus Gukang capsules for primary osteoporosis and its effect on bone metabolic levels in the patients. Method One hundred and nine patients with primary osteoporosis were allocated, using a random number table, to an observation group (56 cases) and a control group (53 cases). The control group received warm needling moxibustion and the observation group, oral administration of Gukang capsules in addition. The course of treatment was 12 weeks in both groups. The therapeutic effects, and pre-treatment and post-treatment bone densities, bone metabolic levels, the VAS scores and the Oswestry Disability Index scores were compared between the two groups. Result The total efficacy rate was higher in the observation group (94.6%) than in the control group (71.7%)(P<0.05). After treatment, lumbar vertebral bone density and femoral neck bone density increased in both groups (P<0.05) and were higher in the observation group than in the control group (P<0.05). After treatment, B-ALP and PINP levels decreased in both groups (P<0.05) and were lower in the observation group than in the control group (P<0.05). After treatment, the VAS score and the Oswestry Disability Index score decreased in both groups (P<0.05) and were lower in the observation group than in the control group (P< 0.05). Conclusion Warm needling moxibustion plus Gukang capsules has a marked therapeutic effect on primary osteoporosis and can improve bone metabolism in the patients.