Fgf22在神经系统中的研究进展及在耳蜗带状突触中的作用

Advances in Research of Fgf22 in the Central Nervous system and its effects on Cochlear Ribbon Synapses

成纤维细胞生长因子22(Fibroblast growth factor 22, Fgf22)是成纤维细胞生长因子家族(Fibroblast growth factor family, Fgfs)的成员之一。Fgf22与哺乳动物胚胎期大脑发育、中枢神经系统兴奋性突触的形成、维持与调控等都有着密切联系,最近研究发现Fgf22与听觉系统耳蜗带状突触密切相关。因此,充分认知Fgf22在神经系统中的研究进展及其在听觉系统耳蜗带状突触中的意义,将为进一步深入探讨相关遗传性疾病的分子机制研究提供重要的理论依据,也将为发现潜在耳聋新基因提供新思路。

Fibroblast Growth Factor 22 (Fgf22) is a member of the Fibroblast Growth Factors (Fgfs) family. It’s reported that Fgf22 plays key roles in the development of the brain, and in the formation, stabilization and control of neural synapses, among other functions. Recently, the Fgf22 gene was reported to play an essential role in protecting mice from ototoxicity-induced hearing loss by maintaining the number of cochlear ribbon synapses. As a consequence, its research will provide theoretical support for further understanding auditory system development and the molecular pathogenesis of related genetic diseases and for understanding the functions of the central nervous and auditory systems. The research will also further brighten a new deafness gene research direction.