抽动秽语综合征共患病的横断面调查研究

Cross-sectional study on comorbidity of tourette syndrome

目的调查了解抽动秽语综合征(TS)共患病情况。方法连续入组2013年6月—2015年5月所有在北京安定医院就诊的TS患儿,并对TS患儿及家长进行横断面调查研究,由临床医师对患儿进行一般人口学信息、TS患病情况及治疗情况等信息进行调查,并进行简明儿童少年神经精神访谈问卷(MINI-Kid)评估。结果414例患儿纳入分析,通过MINI-Kid再诊断后,共患病率为91.30%(378/414),而临床诊断共患病仅为10.39%(43/414);MINI-Kid再诊断后,发现TS共患注意缺陷多动障碍患儿最多,共308例,占总人数的74.40%(308/414);其次分别是重性抑郁障碍、恶劣心境、(轻)躁狂以及强迫症等;临床中TS共患病治疗率低,治疗率最高为共患强迫症状,仅为22.20%(16/72),其次分别是共患注意缺陷多动障碍10.06%(31/308),共患(轻)躁狂发作9.76%(8/82),共患重性抑郁发作3.98%(8/201)。结论TS共患病情况临床识别率低,治疗率也低。

Objective To investigate the comorbidity of Tourette syndrome(TS).Methods From June 2013 to May 2015,all TS patients of Beijing Anding Hospital were recruited.A cross-sectional study was carried out in the TS patients and their parents.The clinician surveyed the patient for general demographic information,TS prevalence and treatment status,and conducted a Mini International Neuropsychiatric Interview for children and adolescents(MINI-Kid)for evaluation.Results A total of 414 patients were included in the analysis.After MINI-Kid re-diagnosis,the prevalence rate was 91.30%(378/414),while the clinical diagnosis of comorbidity was only 10.39%(43/414).After MINI re-diagnosis,it was found that TS had the largest number of patients with Attention Deficit Hyperactivity Disorder(ADHD),a total of 308 cases,accounting for 74.40%of the total number.Followed by major depressive disorder.The treatment rate of TS comorbidity was low in clinical practice.The highest treatment rate for TS comorbidity was obsessive-compulsive symptoms,which is only 22.20%(16/27),following ADHD 10.06%(31/308),manic episodes 9.76%(8/82),and major depressive episodes 3.98%(8/201).Conclusions The clinical recognition rate of TS comorbidity is low and the treatment rate is low.