阿尔茨海默病的脑微血管改变及其对治疗的潜在影响

Microvasculature changes in Alzheimer disease and their potential impact on therapy

阿尔茨海默病(AD)是最常见的痴呆类型,其发病机制至今尚未完全明确。研究表明,在AD病变过程中伴随大量脑微血管结构和功能异常,提示脑微血管改变可能参与了AD的发生与发展。现就AD的脑微血管改变及其对治疗可能的影响作一综述。

Alzheimer disease(AD)is the most common type of dementia,and its pathogenesis is complex and has not been completely clear to date.Studies have shown that a large number of abnormalities in the structure and function of brain microvasculature are associated with AD lesions,suggesting that the changes of brain microvasculature may be involved in the occurrence and development of AD.This article reviews the microvascular changes of AD and its effect on the treatment.