瑞舒伐他汀钙治疗冠心病颈动脉粥样硬化斑块药物剂量研究

Study on dosage of rosuvastatin calcium in the treatment of carotid atherosclerotic plaque in patients with coronary heart disease

目的冠心病患者粥样斑块致使动脉腔变窄,阻碍人体血液流动,造成患者出现心脏缺血和心绞痛等不良反应,影响患者身体健康和生活质量。本研究探讨两种剂量瑞舒伐他汀钙对冠心病患者颈动脉粥样硬化斑块、血脂水平、超敏C反应蛋白(high sensitivity C-reactive protein,hsCRP)水平的影响。方法选取2017-05-01-2018-05-01南京医科大学康达学院附属连云港市东方医院收治的64例冠心病颈动脉粥样硬化斑块患者作为研究对象,将其分为低剂量组和高剂量组,低剂量组给予5mg瑞舒伐他汀钙,高剂量组给予10mg瑞舒伐他汀钙。比较两组治疗前后颈动脉斑块积分、血脂水平和血清hsCRP水平。结果治疗后,低剂量组和高剂量组动脉斑块积分分别(3.21±0.34)和(3.28±0.29)分,差异无统计学意义,t=0.886,P>0.05。治疗后,高剂量组三酰甘油水平为(1.37±0.18)mmol/L,低于低剂量组的(1.58±0.21)mmol/L,t=4.295,P<0.05;高剂量组总胆固醇水平为(3.31±0.43)mmol/L,低于低剂量组的(4.22±0.54)mmol/L,t=7.457,P<0.05;高剂量组低密度脂蛋白水平为(1.81±0.16)mmol/L,低于低剂量组的(2.25±0.27)mmol/L,t=7.931,P<0.05;高剂量组高密度脂蛋白水平为(1.08±0.37)mmol/L,低于低剂量组的(1.26±0.41)mmol/L,t=1.844,P<0.05。治疗后,低剂量组血清hsCRP水平为(6.92±0.47)mmol/L,高剂量组为(6.83±0.51)mmol/L,差异无统计学意义,t=0.734,P>0.05。结论瑞舒伐他汀钙5mg与10mg对冠心病患者颈动脉粥样硬化斑块及hsCRP的影响相同,但高剂量对患者血脂的影响优于低剂量,因此对于血脂水平不高的患者,建议选用5mg服用剂量。

OBJECTIVE Atherosclerotic plaques in patients with coronary heart disease narrow the arterial lumen,hinder the flow of blood,cause adverse reactions such as heart ischemia and angina pectoris,and affect the health and quality of life of patients.The aim of this study is to investigate the effect of different doses of rosuvastatin calcium on carotid atherosclerosis plaque in patients w.h coronary heart disease and its effect on blood lipid and high sensitive C reactive protein(hsCRP).METHODS A total of 64 patients with carotid atherosclerosis plaque of coronary heart disease(CHD)adm.ted to Lianyungang Oriental Hosp.al Affiliated to Kangda College of Nanjing Medical University from May 1,2017 to May 1,2018 were divided into low-dose group and high-dose group.The low-dose group was given 5 mg rosuvastatin calcium and the high-dose group was given 10 mg rosuvastatin calcium.The carotid plaque score,blood lipid level and serum hsCRP level were compared between the two groups before and after treatment.RESULTS After treatment,there was no significant difference in plaque score between low-dose group and high-dose group[(3.21±0.34)and(3.28±0.29)],t=0.886,P>0.05.After treatment,the triglyceride level in the high-dose group was(1.37±0.18)mmol/L,lower than that in the low-dose group(1.58±0.21)mmol/L,t=4.295,P<O.05.The total cholesterol level in the high-dose group was(3.31±O.43)mmol/L,lower than that in the low dose group(4.22±0.54)mmol/L,t=7.457,PVO.05.The level of LDL in high-dose group was(1.81±0.16)mmol/L,lower than that in low dose group(2.25±0.27)mmol/L,t=7.931,PVO.05.The level of HDL in high dose group was(1.08±0.37)mmol/L,lower than that in low dose group(1.26±0.41)mmol/L,t=l.844,P<O.05.After treatment,the serum hsCRP level in low dose group was(6.92±0.47)mmol/L,while that in high dose group was(6.83±0.51)mmol/L,t=0.734,P>0.05.CONCLUSIONS Rosuvastatin calcium 5 mg and 10 mg had the same effect on carotid atherosclerotic plaque and hsCRP in patients with coronary heart disease,but the effect of high dose on blood lipid was better than that of low dose.Therefore,for patients with low blood lipid level,the dosage of 5 mg was recommended.