结肠癌术后辅助化疗的临床效果

Clinical effect of postoperative adjuvant chemotherapy on colon cancer

目的探讨结肠癌术后进行辅助化疗的临床效果。方法选取2016年12月至2017年12月在临汾市人民医院接受手术治疗的结肠癌患者120例,根据术后是否行辅助化疗分为观察组和对照组,每组60例。两组患者均给予手术治疗,在此基础上,观察组在术后给予辅助化疗。观察两组治疗效果。结果观察组治疗有效率为71.67%,对照组治疗有效率为53.33%。观察组治疗有效率明显高于对照组,差异有统计学意义(P<0.05)。两组患者在治疗WHOQOL-BREF评分与治疗前相比均有明显提高(P<0.05),观察组与对照组相比,提高更明显(P<0.05)。治疗后,观察组癌胚抗原(CEA)均显著下降,观察组下降更加明显(P<0.05)。随访三年,观察组复发率为26.67%,无病生存时间为(17.64±4.43)个月;对照组复发率为45.00%,无病生存时间为(14.64±3.64)个月;观察组复发率低于对照组,且无病生存时间长于对照组(P>0.05)。结论结肠癌术后辅助化疗有利于提高手术治疗效果,降低术后复发率,临床上值得推广。

Objective To investigate the clinical effect of adjuvant chemotherapy on colon cancer surgery. Methods A total of 120 colon cancer patients who underwent surgery in Linfen People’s Hospital from December 2016 to December 2017 were enrolled. The patients were divided into observation group and control group according to whether or not adjuvant chemotherapy was given, with 60 cases in each group. Surgical treatment was given to both groups of patients. On this basis, the observation group was given adjuvant chemotherapy after surgery. The therapeutic effects of the two groups were observed. Results The effective rate of treatment in the observation group was 71.67%, and the effective rate in the control group was 53.33%. The effective rate of the observation group was significantly higher than that of the control group, and the difference was significant (P<0.05). The scores of WHOQOL-BREF in the two groups were significantly higher than those before treatment (P<0.05). The improvement in the observation group was more significant than that in the control group (P<0.05). After treatment, the CEA of the observation group decreased significantly, and the decrease of the observation group was more obvious (P<0.05). After three years of follow-up, the recurrence rate of the observation group was 26.67%, and the disease-free survival time was (17.64±4.43) months. The recurrence rate of the control group was 45.00%, and the disease-free survival time was (14.64±3.64) months. The recurrence rate of the observation group was lower than that of the control group, and the disease-free survival time was longer than that of the control group (P>0.05). Conclusions Postoperative adjuvant chemotherapy for colon cancer is beneficial to improve the effect of surgical treatment and reduce the recurrence rate. It is worthy of promotion in clinical practice.