布地奈德雾化吸入联合阿奇霉素治疗儿童肺炎支原体感染后慢性咳嗽的疗效

Effect of budesonide inhalation combined with azithromycin on chronic cough after mycoplasma pneumoniae infection in children

目的探讨布地奈德雾化吸入联合阿奇霉素治疗儿童肺炎支原体(MP)感染后慢性咳嗽的有效性及安全性。方法选取大同市第二人民医院2016年4月至2018年4月收治的MP感染后慢性咳嗽患儿80例,根据随机数表法分为观察组与对照组,每组40例。对照组单用阿奇霉素口服治疗,观察组在对照组基础上联合使用布地奈德混悬液雾化吸入治疗,对比两组患儿治疗21 d后疗效、症状改善情况、MP感染率及不良反应发生率。结果观察组治疗总有效率高于对照组,各症状及体征缓解时间短于对照组,治疗后MP感染率低于对照组,差异均有统计学意义(均P<0.05);两组患儿治疗期间不良反应发生率比较,差异未见统计学意义(P>0.05)。结论布地奈德混悬液雾化吸入联合阿奇霉素口服治疗儿童MP感染后慢性咳嗽效果较单用阿奇霉素好,患儿咳嗽、咯痰等症状更好更快缓解,MP清除率高,且联合用药不会增加药物不良反应,安全可靠。

Objective To investigate the efficacy and safety of budesonide atomization inhalation combined with azithromycin on chronic cough after Mycoplasma pneumoniae (MP) infection in children. Methods Eighty cases of chronic cough after MP infection admitted in the Second People’s Hospital of Datong from April 2016 to April 2018 were selected, and were divided into observation group and control group according to the random number table, with 40 cases in each group. The control group was treated with azithromycin alone, and the observation group was treated with budesonide suspension aerosol inhalation on the basis of the control group, and the curative effect, symptom improvement, MP infection rate and adverse reaction rate of the two groups were compared after 21d treatment. Results The total therapeutic effect in the observation group was higher than that in the control group, and the remission time of symptoms and signs was shorter than that in the control group. After treatment, the MP infection rate was lower than that in the control group, and the differences were significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions The effect of aerosol inhalation of budesonide suspension combined with azithromycin on chronic cough in children with MP infection is better than that of azithromycin alone. The symptoms of cough and phlegm in children are better and faster relieved, MP clearance rate is high. Moreover combined use does not increase incidence of adverse reactions, which is safe and reliable.