血浆同型半胱氨酸与脑梗死及临床指标相关性分析

Correlation analysis of plasma homocysteine with cerebral infarction and related clinical indexes

目的探讨血浆同型半胱氨酸(Hcy)与脑梗死及临床指标的相关性。方法选取2016年6月至2017年11月急性脑梗死患者87例作为研究组,根据患者入院时Hcy水平分为研究组A组(Hcy≥15. 4μmol/L)和研究组B组(Hcy <15. 4μmol/L),选取同期非脑梗死患者50例作为对照组,比较研究组和对照组Hcy水平,并比较研究组A组和研究B组间颈动脉内膜中层厚度(IMT)、叶酸、维生素B12(Vit B12)、脑梗死类型、美国国立卫生研究院卒中量表(NIHSS)、Barthel指数、简易智能精神状态量表(MMSE)水平差异,分析相关性。结果研究组患者Hcy水平高于对照组(P <0. 05)。研究A组患者IMT、NIHSS高于研究B组,叶酸、Vit B12、Barthel指数、MMSE低于研究B组(P <0. 05)。研究A组患者大动脉粥样硬化脑梗死(LAA)发生率高于研究B组(P <0. 05);两组患者心源性脑梗死(CE)、腔隙性脑梗死或小动脉闭塞性脑梗死(SAA)、其他原因性脑梗死(SOE)和不明原因性脑梗死(SUE)发生率比较,差异未见统计学意义(P> 0. 05)。Pearson分析得出,Hcy与IMT、NIHSS、LAA呈正相关性,Hcy与叶酸、Vit B12、Barthel指数、MMSE呈负相关性。结论 Hcy与脑梗死发生及临床指标有明确相关性。

Objective To investigate the relationship between plasma homocysteine(Hcy)andrelated indicators in patients with cerebral infarction and cerebral infarction.Methods Eighty-sevencases of acute cerebral infarction from June 2016 to November 2017 were selected as the research group,according to the level of Hcy admitted to hospital,the patients in study group A(Hcy≥15 umol/L)andstudy group B(Hcy<15 umol/L)were enrolled.Fifty patients with non-cerebral infarction in ourhospital were selected as control group,(Control group)and Hcy levels in the control group.The carotidintima-media thickness(IMT),folic acid,vitamin B12(Vit B12),type of cerebral infarction,NIHStroke Scale(NIHSS),Barthel index,MMSE level difference were compared and the correlation wasanalyzed.Results The Hcy level in study group was higher than that in control group(P<0.05).TheIMT,NIHSS higher in study group A than those in the study group B,the folic acid,Vit B12,Barthelindex,MMSE lower than those in the study group B(P<0.05).The incidence of LAA in study group Awas higher than that in study group B(P<0.05).The incidence of CE,SAA,SOE and SUE was nosignificantly different between the two groups(P>0.05).Pearson analysis showed that Hcy waspositively correlated with IMT,NIHSS and LAA,while Hcy was negatively correlated with folic acid,Vit B12,Barthel index and MMSE.Conclusions Hcy have clear correlation with cerebral infarction andcerebral infarction related clinical indicators.