血清RDW、CRP和CEA检测对结肠癌的诊断价值

Application value of serum RDW,CRP and CEA detection in the diagnosis of colon cancer

目的探讨血清血红细胞分布宽度(RDW)、C-反应蛋白(CRP)和癌坯抗原(CEA)检测对结肠癌的诊断价值。方法选取2017年4月至2018年4月100例结肠癌患者纳入观察组,同期选取100例正常体检人群纳入对照组,对两组患者血清中RDW、CRP和CEA表达水平进行检测,并进行统计学分析。结果观察组RDW、CRP和CEA水平均高于对照组,差异有统计学意义(P <0. 05);不同TNM分期以及分化程度的结肠癌患者的RDW、CRP、CEA水平比较,差异均未见统计学意义(P> 0. 05)。结论结肠癌患者RDW、CRP和CEA水平明显高于正常人群,RDW、CRP和CEA水平检测可以作为早期结肠癌的诊断指标,三者联合检测将会提高结肠癌早期诊断的准确性,为临床治疗提供依据。但RDW、CRP和CEA水平与不同病理组织结肠癌并无明显关系,这一点,在以后的研究中还有待于继续讨论。

Objective To investigate the application value of serum red blood cell distributionwidth(RDW),C-reactive protein(CRP)and carcinoembryonic antigen(CEA)in the diagnosis ofcolon cancer.Methods One hundred patients with colon cancer in the hospital from April 2017 to April2018 were selected as observation group,and 100 normal people with physical examination were selectedas control group.The serum RDW,CRP,CEA expression levels in two groups were detected andanalyzed.Results The levels of RDW,CRP,CEA in observation group were higher than those incontrol group(P<0.05);There was no significant difference in the RDW,CRP,CEA levels amongcolon cancer patients with different TNM staging and differentiation(P>0.05).Conclusions TheRDW,CRP,CEA levels of colon cancer patients are higher than those of normal people,and RDW,CRP,CEA can be used as diagnostic indexes of early colon cancer.The joint detection can increase theearly diagnostic accuracy of colon cancer,so as to provide basis for clinical treatment.But RDW,CRP,CEA levels have no obvious relations with different pathological tissues of colon cancer,which remains tobe discussed in future research.