男性泌尿生殖道分泌物解脲支原体和沙眼衣原体检测结果及耐药性分析

Analysis of the results and drug resistance of Ureaplasma urealyticum and Chlamydia trachomatis in male urogenital secretions

目的:了解男性泌尿生殖道沙眼衣原体(CT)和解脲支原体(UU)感染情况及耐药性,给临床提供最新流行病学资料和用药指导。方法:对2017年1月～2017年12月511例泌尿门诊男性患者的泌尿生殖道分泌物的支原体培养和药敏试验结果及衣原体检测结果进行统计,依据阳性结果和对支原体药敏试验结果进行分析。结果:男性单纯衣原体(CT)感染率为2. 3%,单纯支原体(UU)感染率为34. 2%,衣原体和支原体(CT+UU)混合感染率为0. 6%,男性单纯CT感染和CT+UU混合感染率明显低于单纯UU感染。解脲支原体对12种常用菌药物的敏感率由高到低依次为美满霉素96. 0%、强力霉素95. 4%、交沙霉素91. 4%、克拉霉素90. 3%、四环素88. 6%、莫西沙星85. 7%、加替沙星37. 7%、司帕沙星24. 6%、左氧氟沙星16. 0%、阿奇霉素和罗红霉素4. 0%、环丙沙星1. 7%,UU对美满霉素、强力霉素、交沙霉素、克拉霉素、四环素、莫西沙星敏感性较好,对加替沙星、司帕沙星、左氧氟沙星、阿奇霉素、罗红霉素、环丙沙星耐药率较高。结论:男性泌尿生殖道支原体、衣原体主要以解脲支原体感染为主,美满霉素、强力霉素、交沙霉素、克拉霉素、四环素、莫西沙星敏感性较高,可作为男性支原体感染治疗的首选药物和经验用药。

Objective: To understand the infection and drug resistance of Chlamydia trachomatis( CT) and Ureaplasma urealyticum( UU) in male urogenital tract of Zhengzhou Seventh People’s Hospital,so as to provide the latest epidemiological data and medication guidance for clinic.Methods: The mycoplasma culture and drug sensitivity test results and Chlamydia test results of urogenital tract secretions in 511 urological outpatients from January 2017 to December 2017 were statistically analyzed,based on the positive results and the results of Mycoplasma susceptibility test.Results: The infection rate of male Chlamydia trachomatis( CT) was 2.3%,the infection rate of pure Mycoplasma( UU) was 34.2%,the mixed infection rate of Chlamydia and Mycoplasma( CT + UU) was 0.6%,the rate of simple CT infection and CT + UU mixed infection in male was significantly lower than that in pure UU infection.Ureaplasma urealyticum on 12 common bacteria drug sensitive rate from high to low as minocin,josamycin,doxycycline,96% 95.4%,91.4% 90.3%,88.6%,clarithromycin,tetracycline,gatifloxacin,sparfloxacin,moxifloxacin85.7% 37.7% 24.6%,levofloxacin 16%,azithromycin and roxithromycin,4%,ciprofloxacin 1.7%,UU to minomycin,doxycycline,josamycin,clarithromycin,tetracycline,moxifloxacin,gatifloxacin for better sensitivity,sparfloxacin and levofloxacin,azithromycin,roxithromycin,ciprofloxacin resistance rate is higher.Conclusion: The Seventh People’s Hospital of Zhengzhou male urinary outpatient of urogenital tract mycoplasma and Chlamydia detection in Ureaplasma urealyticum infection,minocycline,doxycycline,josamycin,clarithromycin,tetracycline,moxifloxacin is sensitive,can be used as the preferred drug and drug treatment of mycoplasma infection in male experience.