小儿川崎病实施NT-proBNP、CRP诊断的临床研究

Economic study on the diagnosis of NT-proBNP and C-reactive protein in children with Kawasaki disease

目的:分析小儿川崎病实施N末端B型利钠肽原(NT-proBNP)、C-反应蛋白(CRP)诊断,并研究其临床意义。方法:选择在我院治疗的川崎病急性期患儿20例为急性期组、川崎病恢复期患儿20例为恢复期组,呼吸道感染患儿20例为对照组,比较3组的NT-proBNP和CRP水平,再将川崎病患儿分为无冠脉病变组和冠脉病变组,并比较其NT-proBNP、CRP水平。结果:急性期组和恢复期组的NT-proBNP、CRP水平均明显高于对照组,而急性期组又明显高于恢复期组,组间比较差异均有统计学意义(P<0.05);在急性期组病变检测中发现,有病变患儿的WBC、PLT、CRP水平高于无病变患儿(P<0.05),但NT-proBNP水平并无明显差异(P>0.05);川崎病急性期组中的无冠脉病变组和冠脉病变组的NT-proBNP水平比较,差异无统计学意义(P>0.05);冠脉病变组的CRP水平明显高于无冠脉病变组,两组比较有统计学意义(P<0.05)。结论:小儿川崎病实施NT-proBNP、CRP检测,能够准确判断疾病病变程度,可作为实验室指标和治疗指导,两者联合检测准确性更高,对川崎病诊断和治疗具有重要的临床价值。

Objective: To analyze the diagnosis of NT-proBNP and C-reactive protein in children with Kawasaki disease, and to study its economics and significance. Methods: Twenty patients with acute Kawasaki disease and 20 patients with Kawasaki disease recovery from June 2017 to June 2018 were enrolled in our hospital. Twenty patients with respiratory infection were included in the control group. The levels of proBNP and C-reactive protein were divided into children without Kawasaki disease and coronary artery disease group, and the levels of NT-proBNP and C-reactive protein were compared. Results: The levels of NT-proBNP and C-reactive protein in the acute phase of Kawasaki disease and the recovery group of Kawasaki disease were significantly higher than those in the control group, and the acute phase group was significantly higher than the recovery group. The difference between the groups was statistically significant ( P <0.05). In the detection of lesions in children with acute Kawasaki disease, the levels of WBC, PLT, and CRP in children with lesions were higher than those without lesions. The difference between the detection indexes and the lesions was P <0.05, but NT There was no significant difference in the level of -proBNP ( P >0.05). There was no significant difference in NT-proBNP levels between the non-coronary lesion group and the coronary artery disease group in the acute phase of Kawasaki disease ( P >0.05). The level of C-reactive protein in the group was significantly higher than that in the group without coronary artery disease, and the two groups were statistically significant ( P <0.05). Conclusion: The detection of NT-proBNP and C-reactive protein in children with Kawasaki disease can accurately determine the extent of disease, and can be used as a laboratory index and treatment guidance. The combined detection accuracy of these two is more accurate, and it has important clinical significance for the diagnosis and treatment of Kawasaki disease value.