声辐射力脉冲成像技术在甲状腺乳头状癌的超声表现及与骨桥蛋白表达水平的相关性研究

Ultrasonic findings of papillary thyroid carcinoma and its relationship with osteopontin expression

目的:分析声辐射力脉冲成像(ARFI)技术对甲状腺乳头状癌的超声表现及其与骨桥蛋白表达量(OPNmRNA)的相互关系。方法:选取医院普外科收治的59例经手术病理确诊为甲状腺乳头状癌患者,将其纳入观察组;另选取同期30例甲状腺良性结节患者,将其纳入对照组。采用彩色超声诊断仪对两组患者初歩检查后切换至ARFI下声触诊组织成像(VTI)模式与声触诊组织定量(VTQ)模式,分别测量VTI面积与二维面积比值及VTQ模式下剪切波速度(SWV)值;检测两组患者甲状腺组织中OPN表达量。分析两组病灶边界、形态、内部回声、钙化及血流等指标差异性,分析VTI面积与二维面积比值及SWV值与甲状腺组织中OPNmRNA表达量的相关性。结果:观察组甲状腺乳头状癌结节形态多表现为边界不规则形呈毛刺样改变,结节内部低回声,纵横比>1;对照组良性结节形态多表现为边界清楚,内部呈现中高回声,大部病灶无钙化发生。观察组VTI下面积比值及VTQ下SWV值明显高于对照组,差异有统计学意义(t=7.313、43.334;P<0.05);观察组OPNmRNA表达量明显高于对照组,差异有显著统计学意义(t=8.894,P<0.05)。观察组甲状腺乳头状癌的OPNmRNA表达量与VTI下面积比值和VTQ下SWV值呈显著正相关(r=0.235、0.264;P<0.05)。结论:采用ARFI技术联合OPNmRNA表达量检测可作为甲状腺乳头状癌诊断及预后的新方法。

Objective: The ultrasonic findings of papillary thyroid carcinoma were analyzed by acoustic power pulse imaging, and the relationship between the expression of osteopontin and the expression of osteopontin was analyzed. Methods: Using color Doppler ultrasound in patients with lesions, morphology, internal echo, calcification and blood flow of the situation, and then switch to ARFI VTI mode and VTQ mode, VTI were measured with two-dimensional area and area ratio of VTQ mode SWV;osteopontin expression was detected in two groups of patients with thyroid tissues. Analysis of difference between the two the group index by using SPSS18.0 software, Pearson linear correlation method is used to analyze the area ratio and SWV value of thyroid tissue expression correlated with OPN. Results: The shape of papillary thyroid carcinoma nodules showed that the boundary was irregular and the shape of the nodules was burr. The shape of benign nodules was more than 1 with low echo in the interior. The shape of benign nodules showed clear boundary and middle hyperechoic in the interior. No calcification occurred in most lesions.in that observation group , the area ratio in VTI mode is obviously higher than that of the control group ,The difference was statistically significant ( t =7.313, P = 0.000),The SWV value in the VTQ model of the observation group was also significantly higher than that in the control group,The difference was statistically significant( t =43.334, P =0.000). The expression of OPNmRNA in the observation group was significantly higher than that of the control group , and the difference was statistically significant( t =8.894, P =0.000).Pearson linear correlation analysis showed that there was a significant positive correlation between OPNmRNA expression in papillary thyroid carcinoma and area ratio in VTI model and SWV course in VTQ model( r =0.235,0.264;P <0.05). Conclusion: It is important for the diagnosis of papillary thyroid carcinoma to use the technique of acoustic power pulse imaging combined with the detection of OPNmRNA expression. It can be used as a new method for the diagnosis and prognosis of papillary thyroid carcinoma.