阿托伐他汀治疗老年高血压合并高脂血症高危患者疗效与安全性分析

Efficacy and Safety of Atorvastatin in the Treatment of Elderly Patients with Hypertension and Hyperlipidemia

目的分析老年高血压合并高脂血症高危患者采用阿托伐他汀治疗临床效果及其安全性。方法选取该院2017年4月—2018年7月收治的80例老年高血压合并高脂血症高危患者作为研究对象,随机将患者分为对照组(n=40)和观察组(n=40),将常规药物治疗应用于对照组临床,观察组在常规治疗基础上予以阿托伐他汀治疗,对两组患者的临床治疗效果及安全性进行比较。结果治疗后,观察组患者舒张压(80.42±2.31)mmHg、收缩压(118.34±3.26)mmHg下降均优于对照组(t=5.724、5.242,P<0.05);观察组患者血脂水平改善情况优于对照组(P<0.05);另外,观察组患者不良反应发生率(5.0%)低于对照组(15.0%)(χ~2=5.234,P<0.05)。结论对老年高血压合并高脂血症高危患者阿托伐他汀展开治疗能取得良好效果,其有助于改善患者的临床相关指标,包括甘油三酯、总胆固醇、低密度脂蛋白胆固醇等,能够有效提高患者临床治疗效果,且该药物使用后期不良反应较小,安全性较高。

Objective To analyze the clinical efficacy and safety of atorvastatin in elderly patients with hypertension and hyperlipidemia.Methods 80 patients with high risk of hypertension and hyperlipidemia admitted to our hospital from April 2017 to July 2018 were enrolled. The patients were randomly divided into control group(n=40) and observation group(n=40). The conventional drug treatment was applied to the control group, and the observation group was treated with atorvastatin on the basis of conventional treatment. The clinical treatment effect and safety of the two groups were compared. Results After treatment, the decrease of diastolic blood pressure(80.42±2.31)mmHg and systolic blood pressure(118.34 ±3.26)mmHg in the observation group were better than those in the control group(t=5.724,5.242, P <0.05). The improvement of blood lipid level in the observation group was better than that in the control group(P<0.05);In addition, the incidence of adverse reactions(5.0%) was lower in the observation group than in the control group(15.0%)(χ^2=5.234, P<0.05). Conclusion The treatment of atorvastatin in elderly patients with hypertension and hyperlipidemia can achieve good results, which can improve the clinical indicators of patients, including triglycerides, total cholesterol, low-density lipoprotein cholesterol, etc. effectively improve the clinical treatment effect of patients, and the drug has less adverse reactions and higher safety in the later stage of use.