舒肝颗粒联合Q开关Nd:YAG激光治疗黄褐斑的临床效果分析

Clinical Analysis of Shugan Granule Combined with Q-switched Nd:YAG Laser in the Treatment of Chloasma

目的探讨舒肝颗粒联合Q开关Nd:YAG激光治疗黄褐斑的临床效果。方法选择该院医疗美容科收治的89例黄褐斑患者(2017年1月—2018年6月),随机分为2组,对照组40例患者行Q开关Nd:YAG激光治疗,观察组49例患者行Q开关Nd:YAG激光联合舒肝颗粒治疗,比较两组的临床疗效、皮损评分、皮肤颜色评分、生活质量评分、不良反应、复发率。结果观察组的总有效率为95.92%,较对照组的80.00%更高(χ~2=5.595,P<0.05)。治疗后观察组的皮损评分、皮肤颜色评分、生活质量评分分别为(1.08±0.32)分、(1.15±0.34)分、(9.04±3.27)分,对照组分别为(1.49±0.37)分、(1.54±0.40)分、(13.98±3.85)分,观察组均较对照组更低(t=5.604、4.972、6.545,P<0.05)。观察组与对照组的不良反应总发生率分别为4.08%、10.00%,组间比较差异无统计学意义(χ~2=1.227,P>0.05),但观察组的复发率(2.04%)低于对照组的15.00%(χ~2=5.104,P<0.05)。结论舒肝颗粒与Q开关Nd:YAG激光联合应用可提高黄褐斑的临床疗效,改善其生活质量,还具有良好的安全性,减少复发。

Objective To study the clinical effect of microsurgery for semi-laminectomy in patients with intraspinal tumors. Methods Sev- enty-twg patients who underwent treatment for intraspinal tumors in our hospital were enrolled. The enrollment time was from Febru-ary 2017 to February 2018. They were divided into experimental group and reference group by random number table method, 36 cas-es in each group. The reference group was treated with total laminectomy, and the experimental group underwent micro-surgical mi-crosurgery. The adverse reactions of postoperative symptom scores were compared between the two groups. Results The length of the operation and the length of hospital stay in the experimental group were shorter than the reference group. Compared with the reference group, the experimental group had less bleeding (t=42.634 4, 11.149 9, 50.937 1,P=0.000 0), muscle atrophy, neck pain, exercise in the experimental group of symptoms such as obstacles and numbness were lower than the reference group (t=3.869 3, 2.480 1, 3.464 4, 2.771 9, P=0.000 2, 0.015 5, 0.000 9, 0.007 1). The experimental group had cerebrospinal fluid leakage, infection, muscle weak-ness and other intraspinal tumors reaction rate (5.56%) were higher than that of the reference group (22.22%), and the difference was statistically significant (χ^2=4.180 6, P=0.040 8, P<0.05). Conclusion The use of semi-laminar microsurgery in patients with intraspinal tumors is effective, the symptoms of patients are significantly relieved, and the level of surgical safety is high.