摘要
目的阐明驱动蛋白超家族23(KIF23)基因在胃癌中的表达及意义。方法从0ncomine数据库中提取并挖掘关于胃癌中KIF23基因表达的数据,并利用Kaplan-Meier Plotter探讨其与胃癌预后的关系。结果对Oncomine数据库中搜集12项KIF23基因有表达差异的胃癌和癌旁正常组织数据集在线分析,结果表明KIF23基因在胃癌组织中的表达明显高于癌旁正常组织,差异有统计学意义(P<0.05)。同时,在线生存分析结果表明KIF23基因高表达患者的预后相对更好(P<0.05)。结论KIF23基因在胃癌中高表达,且与胃癌预后有关,可能为药物干预胃癌的一个新靶点。
Objective To explore the expression and significance of kinesin family member 23 (KIF23) in gastric cancer.Methods The KIF23 gene expression data in gastric cancer were retrieved and collected from Oncomine database.The relationship between the expression of K1F23 and prognosis of gastric cancer were analyzed using an online survival analysis tool Kaplan-Meier Plotter.Results On-line analysis of 12 K1F23 gene datasets collected from Oncomine database showed that the expression of KIF23 gene in gastric cancer tissues was distinctly higher than that of gastric adjacent normal tissues (P<0.05).Meanwhile, online survival analysis showed that the patients with low KIF23 gene expression had a better prognosis (P<0.05).Conclusions KIF23 gene is highly-expressed in gastric cancer and its expression level is closely associated with the prognosis of gastric cancer patients, which may be a new target for drug intervention in gastric cancer.
作者
王文龙
王洪倩
向庆东
卢宏达
刘殿雷
余涛
雷章
吴洪斌
孔庆志
WANG Wenlong;WANG Hongqian;XIANG Qingdong;LU Hongda;LIU Dianlei;YU Tao;LEI Zhang;WU Hongbing;KONG Qingzhi(Clinical College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Wuhan,Hubei 430065,China;Intensive Care Unit,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou,Zhejiang 310007;the Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053;College of Acupuncture and Orthopedics,Hubei University of Chinese Medicine,Wuhan,Hubei 430065;Department of Oncology,Wuhan Central Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430014;Wuhan Oncology Institute,Wuhan,Hubei 430014;Department of Surgery,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou,Zhejiang 310007;School of Basic Medical Sciences,Hubei University of Chinese Medicine,Wuhan,Hubei 430065)
出处
《徐州医科大学学报》
CAS
2019年第3期162-165,共4页
Journal of Xuzhou Medical University
基金
国家自然科学基金(81372931)
国家自然科学基金青年科学基金(81704023)
浙江省科技厅基础公益项目(GD19H160018)
浙江省卫生计生委医药卫生科研面上项目(2018KY615)
浙江省中医药管理局中医药科技计划项目(2018ZB091)
杭州市卫生科技计划项目(2017A59)
