七氟醚吸入全身麻醉对老年手术患者术后认知功能的影响

Effect of General Anesthesia of Sevoflurane Inhalation on the Postoperative Cognitive Function of Senile Surgical Patients

目的分析老年手术患者行七氟醚吸入全身麻醉的临床价值,评定对患者术后认知功能的影响。方法分析2015年12月—2018年12月期间在该院接受手术进行麻醉的老年患者100例,根据双盲法的分组形式将其平均分为实验组和参照组,每组各为50例。实验组手术行七氟醚吸入全身麻醉处理,参照组行静脉丙泊酚麻醉处理,对比两组患者手术后的临床指标,如呼吸恢复用时、清醒时间、定向力恢复用时等,同时比较麻醉后6小时、半日以及1日的MMSE分数变化情况等。结果两组患者术后苏醒指标分析中,实验组呼吸恢复用时、清醒时间、定向力恢复用时分别为(12.1±2.3)min、(13.2±2.7)min、(15.3±3.1)min;参照组上述指标分别为(14.5±3.6)min、(15.3±4.6)min、(17.6±4.7)min,组间对比差异有统计学意义(t=3.972 5、2.783 9、2.888 5,P<0.05);手术后MMSE评分分析,实验组12 h(26.8±5.5)分、1 d为(28.5±6.1)分,参照组(23.2±4.6)分、(28.3±5.2)分。血清S100β指标变化对比,麻醉前不存在差异性(t=0.452 6,P=0.6518),麻醉后参照组为(0.097±0.011),实验组为(0.055±0.014),组间对比差异有统计学意义(t=16.680 3,P<0.05)。结论七氟醚吸入全身麻醉后,苏醒质量有显著改善,手术后认知功能指标恢复显著,适用于老年患者,在临床推广价值显著。

Objective To analyze the effect of general anesthesia of sevoflurane inhalation on the postoperative cognitive function of senile surgical patients.Methods 100 cases of senile patients for surgery in our hospital from December 2015 to December 2018 were selected and randomly divided into two groups with 50 cases in each,the experimental group used the general anesthesia of sevoflurane inhalation,while the control group used the intravenous propofol anesthesia for treatment,and the clinical indexes such as the respiration recovery time,awakening time and recovery time of directive force were compared between the two groups,and the MMSE score changes in 6 hours,12 hours and 24 hours after anesthesia were compared.Results The respiration recovery time,awakening time and recovery time of directive force in the experimental group and in the control group were respectively(12.1±2.3)min,(13.2±2.7)min,(15.3±3.1)min and(14.5±3.6)min,(15.3±4.6)min,(17.6±4.7)min,and the differences were obvious(t=3.972 5,2.783 9,2.888 5,P<0.05);after surgery,the MMSE score in 12 hours and 24 hours in the experimental group and in the control group were respectively(26.8±5.5)min,(28.5±6.1)min and(23.2±4.6)min,(28.3±5.2)min,and the differences were statistically significant(t=4.240 6,3.550 2,P<0.05),and the differences in the serum S100βchanges before and after anesthesia were not obvious(t=0.452 6,P=0.651 8),and the index in the control group and in the experimental group after anesthesia was respectively(0.097±0.011)and(0.055±0.014),and the differences were statistically significant(t=16.680 3,P<0.05).Conclusion The awakening quality is obviously improved after the general anesthesia of sevoflurane inhalation,and the recovery of the cognitive function indexes after surgery is obviously improved,and it is suitable for senile patients,and it is of obvious promotion value.