糖皮质激素治疗小儿难治性支原体肺炎的效果分析

Analysis of Effect of Glucocorticoid in Treatment of Children with Refractory Mycoplasma Pneumonia

目的观察分析对小儿难治性支原体肺炎患者实施糖皮质激素治疗的效果。方法从2017年1月—2018年4月该院收治的小儿难治性支原体肺炎患者中选取122例患者作为研究对象,采用随机数表法进行分组,对照组患者61例,采用头孢呋辛联合阿奇霉素药物进行治疗,实验组患者61例,在对照组的基础上加用泼尼龙药物进行治疗。对比两组患者的临床症状改善时间、住院时间、炎症指标与治疗效果。结果实验组患者的退热时间(2.25±0.89)d、肺部啰音消失时间(4.57±1.12)d、肺部阴影消失时间(8.54±2.31)d、咳嗽症状消失时间(5.45±1.51)d、住院时间(10.56±2.87)d、血沉水平(24.15±2.12)mm/h、中性粒细胞水平(52.71±3.14)%与C反应蛋白水平(15.71±2.73)mg/L均小于对照组的(3.95±1.12)d、(6.34±1.41)d、(10.23±2.79)d、(8.87±2.42)d、(13.98±3.47)d、(48.23±3.61)mm/h、(77.15±2.41)%与(67.23±7.42)mg/L,差异有统计学意义(t=9.281 3,t=7.677 1,t=3.644 0,t=9.364 2,t=5.931 7,t=44.923 5,t=48.224 0,t=50.894 2,P<0.05);实验组患者的治疗总有效率为95.08%高于对照组的73.77%,治疗效果显著,差异有统计学意义(χ~2=10.535 5,P<0.05)。结论对小儿难治性支原体肺炎患者采用糖皮质激素进行治疗的效果显著,有效的减少了患者的临床症状改善时间,缩短了患者的住院时间,改善了患者的炎症指标,提高了治疗效果,具有临床推广应用价值。

Objective To observe and analyze the effect of glucocorticoid in treatment of children with refractory mycoplasma pneumonia.Methods 122 cases of children with refractory mycoplasma pneumonia treated in our hospital from January 2017 to April 2018 were selected and randomly divided into two groups with 61 cases in each,the experimental group were treated with cefuroxime combined with azithromycin,while the experimental group were treated with prednisolone on the basis of the control group,and the improvement time of clinical symptoms,length of stay,inflammation index and treatment effect of the two groups was compared.Results The antipyretic time(2.25±0.89)d,disappearance time of lung rales(4.57±1.12)d,pulmonary shadow disappearance time(8.54±2.31)d,cough symptoms disappearance time(5.45±1.51)d,length of stay(10.56±2.87)d,erythrocyte sedimentation rate(24.15±2.12)mm/h,neutrophil level(52.71±3.14)%and C reactive protein level(15.71±2.73)mg/L were lower than those in the control group,[(3.95±1.12)d,(6.34±1.41)d,(10.23±2.79)d,(8.87±2.42)d(13.98±3.47)d,(48.23±3.61)mm/h,(77.15±2.41)%,(67.23±7.42)mg/L,the different was statistically significant(t=9.281 3,t=7.677 1,t=3.644 0,t=9.364 2,t=5.931 7,t=44.923 5,t=48.224 0,t=50.894 2,P<0.05)],and the total treatment effective rate in the experimental group was higher than that in the control group 95.08%vs 73.77%,the different was statistically significant(χ^2=10.535 5,P<0.05).Conclusion The effect of glucocorticoid in treatment of children with refractory mycoplasma pneumonia is obvious,which can effectively reduce the improvement time of clinical symptoms,shorten the length of stay,improve the inflammation index and improve the treatment effect,and it is of promotion and application value.