原发性胎儿胸腔积液的产前干预诊疗进展

The prenatal intervention progress of primary fetal hydrothorax

原发性胎儿胸腔积液(PFHT)是一种比较罕见的先天性疾病,常见于乳糜渗漏,与胸导管发育异常、胸腔内淋巴液产生过多或排出功能异常等因素相关,其临床转归差异较大,目前国内外对于PFHT的治疗方案尚未达成共识。现对PFHT的产前超声影像学表现、产前诊断流程、产前干预指征、产前干预方式以及预后评估进行综述,并结合广东省妇幼保健院单中心的诊治对策和处理原则,以期为PFHT的诊疗提供帮助。

Primary fetal hydrothorax(PFHT) is an uncommon congenital disease.Fetal hydrothorax is thought to be due to leakage of lymphatic fluid in the pleural space either caused by direct leakage of lymphatic fluid from the thoracic duct, overproduction or impaired drainage of lymph.The outcome of fetal hydrothorax may vary from spon-taneous resolution without postnatal morbidity to severe fetal hydrops and perinatal death.At present, there is no consensus on the treatment of PFHT.Now, the latest researches progress on prenatal ultrasonographic characteristics, prenatal diagnostic procedures, prenatal intervention, and prognosis in PFHT, were reviewed combined with the diagnosis and treatment principle of single center in Guangdong Women and Children′s Hospital, which would provide useful guidance for clinical treatment of PFHT.