T细胞免疫球蛋白黏蛋白分子-1在免疫调节和肿瘤进展中的作用

The role of T cell immunoglobulin and mucin domain 1 in immune regulation and cancer progression

T细胞免疫球蛋白黏蛋白分子(TIM)-1基因家族在调节免疫应答中发挥重要作用,包括变态反应、哮喘、自身免疫病、移植耐受、病毒感染的免疫应答和癌症密切相关。研究表明,TIM-1主要表达在多种免疫细胞和肿瘤细胞上。TIM-1在免疫细胞表面通过与相应配体结合,促进或抑制肿瘤免疫应答;在某些特殊组织细胞中TIM-1上调可能诱导细胞恶变。本综述介绍TIM-1在不同细胞表面发挥的不同作用,并探讨其对肿瘤发生、发展的影响,为肿瘤治疗提供新的思路。

T cell immunoglobulin and mucin domain (TIM)-1 gene family mainly plays immune regulatory roles, including allergy, asthma, autoimmune diseases, transplant tolerance, the response to viral infections, and cancer. Recent studies have shown that TIM-1 is mainly expressed on several sorts of immune cells and tumor cells. TIM-1 was shown to be able to either promote or inhibit a variety of anti-tumor immune responses by binding to corresponding plasmic membrane ligands expressed by immune cells. Upregulation of TIM-1 might induce tumorigenesis in certain tissue cells. In this review, we attempted to describe various functions exerted by TIM-1 on different cell membranes, discuss their effects on tumorigenesis and tumor progression, and provide new ideas for cancer treatment.