益生菌对56例腹膜透析患者蛋白质-能量消耗和微炎症状态的作用研究

The role of probiotic on protein energy wasting and micro-inflammation in peritoneal dialysis patients

目的探讨益生菌对腹膜透析患者蛋白质-能量消耗和微炎症的影响。方法将2017年1月至2017年12月在贵州省人民医院肾内科收治的112例腹膜透析患者随机分为干预组(56例)和对照组(56例),分别给予益生菌和安慰剂治疗2个月。收集治疗前后患者血生化、炎症、体格测量和人体生物电阻抗指标。结果干预组和对照组蛋白质能量消耗患病率分别为64.29%和60.71%。与对照组相比,治疗后干预组患者尿素氮、三酰甘油、低密度脂蛋白胆固醇、超敏C反应蛋白、白介素-6显著降低,血清白蛋白明显升高,差异有统计学意义(P<0.05)。体格测量结果显示,干预组患者上臂肌围较对照组相比明显升高,差异有统计学意义(P<0.05)。生物电阻抗法检测结果显示,干预组体脂量明显高于对照组(P<0.05)。结论维持性腹膜透析患者服用益生菌可以改善患者的蛋白质-能量消耗和微炎症状态。

Objective To investigate the effect of probiotic on protein energy wasting and micro-inflammation in peritoneal dialysis patients.Methods One hundred and twelve patients who underwent peritoneal dialysis at the nephrology department of Guizhou provincial people’s hospital in 2017,were randomly divided into intervention group(n=56)and control group(n=56),which were treated probiotic and placebo respectively two months,and collected biochemical,inflammatory,physical measurement and bioelectrical impedance index before and after treatment.Results The prevalence of protein-energy wasting was 64.29% and 60.71%in intervention group and control group,respectively.Compared with control group,patients in intervention group had lower urea nitrogen,triglyceride,low density lipoprotein,high-sensitivity C-reactive protein and interleukin-6 and higher serum albumin levels,and these differences were statistically significant(P<0.05).Physical measurement results showed that the upper arm muscle circumference of intervention group was increased compared to control group,and the change was statistically significant(P<0.05).Biological resistance testing results showed that the fat percentage of intervention group was significantly higher than that of control group(P<0.05).Conclusion The treatment of probiotic could improve protein energy wasting and micro-inflammation in continuous peritoneal dialysis patients.