儿童非酒精性脂肪肝研究进展

Research progress of non-alcoholic fatty liver disease in children

非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)被认为是成人和儿童最常见的肝脏疾病之一,它是一种涉及范围广泛的多因素疾病,从简单的脂肪变性到非酒精性脂肪肝炎,以组织病理学发现炎症和纤维化为主要表现。目前其发病机理和进展尚不完全清楚,对肝脏疾病的全面了解可能有助于开发新的治疗方法和非侵入性诊断工具。肝脏组织活检仍然是诊断疾病分期的金标准,虽然生活方式和饮食习惯的改变是NAFLD疾病治疗的关键,但新药的开发可能会对一线治疗失败的患者有帮助。

Nonalcoholic fatty liver disease is considered to be one of the most common causes of liver disease in adults and children.It is a multivariate disease involving a wide range of factors,from simple fatty degeneration to non-alcoholic steatohepatitis(NASH),and histopathology to identify inflammation and fibrosis as major manifestations.The mechanism of pathogenesis and progression of the disease is not fully understood,and a comprehensive understanding of liver disease may contribute to the development of new therapeutic methods and non-invasive diagnostic tools.Liver biopsy is the gold standard of disease staging still,although the changes in lifestyle and diet habit is the key to the treatment of alcoholic fatty liver disease,but the development of new drugs may help first-line treatment failure in patients.