复方异丙托溴铵雾化吸入治疗COPD急性加重期

Clinical Analysis of Compound Ipratropium Bromide Inhalation in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:分析复方异丙托溴铵不同雾化吸入方式治疗慢性阻塞性肺疾病(COPD)急性加重期的临床实践效果。方法:选取广东医科大学附属医院2017年7月至2018年7月收治的80例COPD急性加重期患者,均应用复方异丙托溴铵雾化吸入治疗,按照不同雾化吸入方式将其分为对照组与观察组,每组均为40例,对照组应用氧气雾化吸入,观察组应用压缩空气式雾化器雾化吸入,对比两组患者的临床疗效与血气分析指标。结果:对照组的总有效率是87.5%,观察组是90.0%,组间比较,差异无统计学意义(P> 0.05);观察组治疗后的氧分压(PaO_2)与对照组比较,差异无统计学意义(P> 0.05),但二氧化碳分压(PaCO_2)低于对照组,差异具有统计学意义(P <0.05)。结论:复方异丙托溴铵不同雾化吸入方式治疗慢性阻塞性肺疾病急性加重期的临床实践效果相当,压缩空气式雾化器雾化吸入治疗可明显改善患者的PaCO_2。

Objective To analyze the clinical effect of different inhalation methods of compound ipratropium bromide in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD). Methods 80 patients with acute exacerbation of chronic obstructive pulmonary disease treated in affiliated hospital of Guangdong medical university from July 2017 to July2018 were divided into control group and observation group according to different inhalation methods. Each group has 40 cases.The control group was treated with oxygen inhalation. The observation group was treated with compressed air inhalation. Nebulizer atomization inhalation, compared two groups of patients with clinical efficacy, blood concentration and blood gas analysis indicators.Results The total effective rate was 87.5 % in the control group and 90.0 % in the observation group, which was slightly higher than that in the control group(P > 0.05). After treatment, PaO2 in the observation group was similar to that in the control group,with no significant difference(P > 0.05), but PaCO2 was superior to that in the control group, with significant difference(P < 0.05).Conclusion Different inhalation methods of compound ipratropium bromide have the same clinical effect in the treatment of acute exacerbation of COPD. Compressed air nebulizer can obviously improve the PaCO2 of patients and can be used as the preferred inhalation method.