岭南地区子宫内膜异位症与体质相关性研究

Correlation of Traditional Chinese Medicine Constitution with Pathogenesis of Endometriosis in Lingnan Area

【目的】探索岭南地区子宫内膜异位症(EM)的体质分布规律及与发病的相关性。【方法】采用北京中医药大学王琦教授创建的"中医体质量表",对816例EM患者(病例组)和506例健康女性(对照组)进行体质研究,并根据中华中医药学会发布的《中医体质分类与判定标准》进行体质分类及判定。【结果】(1)816例EM患者按体质出现频次分布前5位的体质为阳虚质、气虚质、湿热质、气郁质、痰湿质,是EM的高发体质;506例健康女性中按体质出现频次分布前5位的体质为平和质、气虚质、阳虚质、湿热质、痰湿质,其中以平和质最为常见。2组间平和质、阳虚质、痰湿质、湿热质、血瘀质、气郁质比较,差异有统计学意义(P<0.05或P<0.01);气虚质、阴虚质、特禀质比较,差异无统计学意义(P>0.05)。(2)进一步行二元Logistic回归分析,结果显示:阳虚质、血瘀质、气郁质与EM发病呈正相关(B>1),差异有统计学意义(P<0.05或P<0.01),而平和质、痰湿质、湿热质与EM发病相关性比较,差异无统计学意义(P>0.05)。【结论】岭南地区EM患者与健康女性的体质分布上存在有明显不同,阳虚质、血瘀质、气郁质与EM发病呈正相关,是EM发病的危险体质。

Objective To explore the distribution of traditional Chinese medicine(TCM)constitution and its correlation with the pathogenesis of endometriosis(EM)in Lingnan area(the south of five ridges).Methods By using Traditional Chinese Medicine Constitution Scale created by Professor WANG Qi from Beijing University of Chinese Medicine,we made the survey in 816 EM patients(case group)and 506 healthy women volunteers(control group).The classification and identification of constitution types were performed by using the Criteria for Classification and Identification of Traditional Chinese Medicine Constitution issued by China Association of Chinese Medicine.Results(1)The leading 5 constitution types in 816 EM patients were Yang deficiency constitution,Qi deficiency constitution,damp heat constitution,Qi stagnation constitution,and phlegm dampness constitution,which were frequently seen in EM patients.The leading 5 constitution types in 506 healthy women volunteers were harmony constitution,Qi deficiency constitution,Yang deficiency constitution,damp heat constitution,and phlegm dampness constitution,and harmony constitution was frequently seen in healthy women volunteers.The differences of harmony constitution,Yang deficiency constitution,phlegm dampness constitution,damp heat constitution,blood stasis constitution,and Qi stagnation constitution between the two groups were statistically significant(P<0.05 or P<0.01),while the differences of Qi deficiency constitution,Yin deficiency constitution,and specific constitution were insignificant(P>0.05).(2)The results of binary Logistic regression analysis showed that the Yang deficiency constitution,blood stasis constitution,and Qi stagnation constitution were positively correlated with the pathogenesis of EM(B>1),the difference being significant(P<0.05 or P<0.01);the harmony constitution,phlegm dampness constitution,and damp heat constitution were not correlated with the pathogenesis of EM,the difference being insignificant(P>0.05).Conclusion There are significant differences in TCM constitution distribution between the EM patients and healthy women volunteers from Lingnan area,and Yang deficiency constitution,blood stasis constitution,and Qi stagnation constitution are positively correlated with the pathogenesis of EM,which are the risk constitution of EM.