血清和糖皮质激素调节蛋白激酶1表达水平与非小细胞肺癌患者预后的关系

Relationship between serum and glucocorticoid-regulated kinase 1 expression and prognosis in patients with non-small cell lung cancer

目的探讨血清和糖皮质激素调节蛋白激酶1(SGK1)表达水平对非小细胞肺癌(NSCLC)患者预后的影响,为NSCLS患者预后评估提供新的生物学预测指标。方法回顾性分析2011年1月-2013年12月来汉中三二0一医院肿瘤科接受手术切除治疗的120例NSCLC患者的临床资料,其中男性75例,女性45例,年龄(63.15±16.44)岁,年龄范围45~80岁。根据免疫组织化学染色结果判定积分确定的SGK1截断值,将NSCLS患者分为SGK1高表达组(n=TO)和SGK1低表达组(a=50)。分析NSCLC组织中SGK1表达水平与临床病理特征[年龄、性别、吸烟史、嗜酒史、体重指数(BMI)、组织类型、肿瘤直径、T分期、N分期、TNM分期、分化程度]的关系,并比较NSCLC组织中SGK1表达水平与总生存率的关系。采用电话或患者入院就诊的方式进行随访,随访时间截至2018年6月1日。患者术后每隔3~6个月复查1次胸部X线、超声,若结果异常则行增强CT或MRI复查。符合正态分布的计量资料采用t检验,以均数±标准差(ilfem±SD)表示;计数资料采用Х^2检验;以5年患者总生存率为终点事件进行单因素分析,对单因素分析有意义的变量应用C0X风险比例模型进行多因素分析。采用Kaplan-Meier法进行累积生存曲线绘制,用Log-rank法进行差异性检验。结果组织中SGK1表达水平与年龄、性别、吸烟史、嗜酒史、BMI、组织类型、肿瘤直径无关(P>0.05),与T分期、N分期、TNM分期、分化程度有关(P<0.05)。单因素、多因素C0X风险比例模型结果显示,TNM分期、SGK1表达水平是影响NSCLC患者5年总生存率的独立因素(P<0.05)。Kaplan-Meiei法生存曲线结果显示,NSCLC组织中SGK1低表达组5年总生存率显著高于SGK1高表达组(P<0.05)。结论组织中SGK1表达水平与NSCLC患者预后密切相关,组织中SGK1高表达不利于NSCLC患者预后。

Objective To investingate the effect of SGK1 expression level on the prognosis of patients with NSCLC,and provide new biological predictors for the prognosis assessment of patients with NSCLS.Methods One hundred and twenty patients with NSCLC received radical resection in Hanzhong 3201 hospital from Jan 2011 to Dec 2013 were selected.There were 75 males and 45 females,age(63.15±16.44)years,age range 45-80 years.According to the results of immunohistochemical staining,the SGK1 cut-off value determined by the integral was determined,and NSCLC patients were divided into SGK1 high expression group(n=70)and SGK1 low expression group(n=50).The relationship between the expression of SGK1 and clinicopathological features(age,sex,smoking history,alcoholism history,BMI,tissue type,tumor diameter,T stage,N stage,TNM stage,differentiation degi'ee)in NSCLG were analyzed,and the overall survival rate in NSCLC were also analyzed.Followup was earned out by telephone or patient admission.The follow-up period was up to June 1,2018.Chest X-ray and ultrasonography were reviewed eveiy 3 to 6 months after operation,and enhanced CT or MRI were performed if the results were abnormal.The measurement data conforming to normal distribution were expressed by i test and showed by±SD);the counting data were tested by;^2 test;the 5-year overall survival rate was used as the endpoint event for univariate analysis,and the significant valuables for univariate analysis were analyzed by COX risk ratio model for multivariate analysis.The cumulative survival curve was drawn by Kaplan-Meier method,and the difference was tested by Log-rank method.Results The expression level of SGK1 in tissues was not related to age,sex,smoking history,alcoholism,BMI,tissue type and tumor diameter(P>0.05),but it was related to T stage,N stage,TNM stage and differentiation degree(P<0.05).The univariate and multivariate COX risk ratio model showed that TNM stage and SGK1 expression were independent factors affecting the 5-year overall survival rate of NSCLC patients(P<0.05).The results of Kaplan-Meier survival curve showed that the 5-year overall survival rate in NSCLC with low expression of SGK1 was significantly higher than that in NSCLC with high expression of SGK1(P<0.05).Conclusions The expression of SGK1 in tissues is closely related to the prognosis of patients with NSCLG.The high expression of SGK1 in tissues is not conducive to the prognosis of patients with NSCLC.