炎症因子在癫痫中的作用研究进展

Advances in research of inflammatory factors in epilepsy

癫痫是一种突发性神经元异常放电引起大脑功能障碍的神经系统疾病,病因多样,其中炎症反应与癫痫的发生发展关系密切。大量研究证实,受损神经元组织中炎症细胞浸润和分子调节机制紊乱是癫痫发生的关键因素。因此炎症因子,如白细胞介素、前列腺素、血小板活化因子、CD40与CD44、基质金属蛋白酶-9、Toll样受体、趋化因子等可能通过不同的机制创造有利于癫痫发作的微环境,使癫痫发作易感性增加。这些指标在癫痫发作过程中有着不同的变化。该文综述了可能参与癫痫发生发展的炎症因子,阐述了癫痫发生中炎症的生物学指标,有助于开发新的生物标志物和筛选具有癫痫风险的患者,为防治癫痫提供新的选择。

Epilepsy is a neurological disease characterized by abnormal brain discharge caused by brain dysfunction.The causes are diverse,and the inflammatory response is closely related to the occurrence and development of epilepsy. A large number of studies have confirmed that inflammatory cell infiltration and molecular regulation mechanisms in damaged neuronal tissues are the key factors for epileptogenesis. Therefore,such inflammatory factors as interleukins,prostaglandins,platelet activating factor,CD40 and CD44,matrix metalloproteinase-9,Toll-like receptors and chemokines may create a microenvironment conducive to seizures through different mechanisms,thus increasing the susceptibility of epilepsy to seizures. These indicators vary during seizures. This article reviews the inflammatory factors that may be involved in the development of epilepsy,and describes the biological indicators of inflammation in epileptic seizures in order to help develop new biomarkers and screen patients at risk of epilepsy,providing new options for the prevention and treatment of epilepsy.