DA、5-HT、BNDF相关基因多态性与甲基苯丙胺成瘾者暴力行为及情绪特征的关联性研究

Association of DA,5-HT,BNDF related gene polymorphisms with violence behaviors and emotional characteristics in methamphetamine addicts

目的:研究DA、5-HT、BNDF相关基因多态性与甲基苯丙胺成瘾者暴力行为及情绪特征的关联性。方法:获的吸毒人员600人,通过MOAS评分确定最终纳入暴力组还是非暴力组,采用PCR-DNA测序方法检测DA、5-HT、BNDF相关基因多态性。结果:卡方检验结果显示,5-HT2A受体基因rs6313、MAOA rs1137070、DRD4受体基因rs1800955及BDNF基因rs6265位点基因多态性与甲基苯丙胺成瘾者的暴力行为之间存在关联(P <0. 05),多因子降维法(MDR)分析显示暴力组与非暴力组"rs6313-rs626"、"同伴暴力-rs6313"及"父母吸毒/酗酒-rs6313-rs6265"的两种组合模型有统计学意义(P <0. 05)。结论:同伴暴力行为、父母吸毒/酗酒可能联合DA、5-HT、

Objective: To investigate the association of DA,5-HT and BNDF-related gene polymorphisms with aggressive behaviors and emotional characteristics in methamphetamine addicts.Methods: Using the dynamic control system of drug addicts in Liaoning Province from January to December 2017,600 methamphetamine addicts were randomly selected. Methamphetamine addicts were evaluated by Modified Overt Aggression Scale( MOAS) and then were divided into aggression group and non-aggression group,respectively. Polymorphisms of DA,5-HT and BNDF related genes were detected by PCR-DNA sequencing.Results: The results of Chi square test showed that 5-HT2 A rs6313,MAOA rs1137070,DRD4 rs1800955 and BDNF rs6265 polymorphism were associated with violence in methamphetamine addicts( P < 0. 05). Multifactor dimensionality reduction revealed that three pattern( rs6313/rs6265,violence friend/rs6313,parental alcohol or drug abuse/rs6313/rs6265) had statistical significance( P < 0. 05).Conclusion: In summary,peer violent acts and parental alcohol or drug abuse may be associated with DA,5-HT and BNDF-related gene polymorphisms,which increase the risk of aggressive behaviors among methamphetamine addicts.