帕金森病轻度认知功能障碍的研究进展

The research progress of mild cognitive impairment in Parkinson's disease

帕金森病(PD)是一种以黑质多巴胺能神经元变性、缺失和路易体形成为病理特征的神经退行性疾病,临床表现除运动症状外,还包括非运动症状。认知功能障碍(PD-CI)是帕金森病患者最常见的非运动症状之一。其分为轻度认知功能障碍(PD-MCI)和痴呆(PDD)。PD-MCI是帕金森病痴呆的早期表现,因此早期诊断和治疗PD-MCI对帕金森病的预后非常重要。本文就PD-MCI的流行病学、危险因素、遗传、生物学标志物、影像学、诊断及治疗作一综述。

Parkinson's disease (PD) is a neurodegenerative disease characterized by degeneration and deletion of dopaminergic neurons in the substantia nigra and a pathological feature of the Louis body. The clinical manifestations including non motor symptoms and motor symptoms. Cognitive impairment (CI) is one of the most common non motor symptoms in patients with PD, Which includes mild cognitive impairment (MCI) and dementia. MCI is an early manifestation of dementia in PD. Therefore, early diagnosis and treatment of MCI are very important for the prognosis of PD. The epidemiology, risk factors, heredity, biomarkers, imaging, diagnosis and treatment of MCI in PD are reviewed in this paper.