高血压视网膜病变与胱抑素C相关性研究

Correlation of retinopathy and serum cystatin C in patients with primary hypertension

目的分析高血压视网膜病变(HRP)的特点,探讨其与高血压患者血清胱抑素C(Cys-C)水平的相关性。方法选取济南市第二人民医院2015年7月到2017年10月收治的280例高血压患者为研究对象,通过眼底镜及眼底照相进行眼底检查,根据《中华眼科学》(第三版)将高血压视网膜病变分为正常、轻度、中度、恶性四个级别,检测Cys-C水平,分析所有患者临床资料、不同级别视网膜病变的特点及相关因素。结果在纳入的病例中,有204例存在HRP,占72.86%,正常眼底组血清Cys-C为(0.76±0.12),HRP轻度组为(0.82±0.19)mg/L,两组差异有统计学意义(t=2.424,P<0.05),中度组和重度组血清Cys-C分别为(2.37±0.13)mg/L和(3.24±0.45)mg/L,与正常眼底组差异均有统计学意义(t=80.917、42.153,均P<0.01)。结论高血压患者视网膜病变的严重程度与Cys-C呈正相关。

Objective To analyze the features of hypertensive retinopathy (HRP), and to evaluate the correlation of serum cystatin C (Cys-C) and retinopathy in patients with primary hypertension. Methods From July 2015 to October 2017, 280 cases of primary hypertension in the Second People′s Hospital of Ji′nan were recruited to receive fundus examination by funduscopy and eye-ground photography.Based on the findings, 4 groups were established according to Chinese Ophthalmology (Third Edition) classification standard, normal, mild, moderate and malignant four levels.Clinical courses were monitored and Cys-C levels were determined. Results There were 204 cases of HRP, accounting for 72.86%.Compared with that of the normal fundus group (0.76±0.12)mg/L, the serum Cys-C level of the mild HRP group was (0.82±0.19)mg/L, the difference was statistically significant (t=2.424, P<0.05). The serum Cys-C levels of the moderate HRP group and severe HRP group were (2.37±0.13)mg/L and (3.24±0.45)mg/L, respectively, the differences were statistically significant compared with that of the control group (t=80.917, 42.153, all P<0.01). Conclusion The severity of HRP is positively correlated with Cys-C.