胺碘酮在快速型心律失常急诊治疗中的应用效果及安全性研究

Effect and safety of amiodarone in emergency treatment of tachyarrhythmia

目的探讨快速型心律失常患者于急诊治疗中应用胺碘酮治疗的效果、安全性。方法对晋中市第一人民医院2017年3月至2018年3月收治的急诊快速型心律失常112例患者临床资料加以分析,按照不同治疗方案分成两组,将56例行常规急救治疗患者设为对照组,将56例在对照组基础上行胺碘酮治疗患者设为观察组,对两组疗效、血压、心率和安全性进行比对、分析。结果观察组总有效率91.07%,比对照组的69.64%高(χ^2=8.145,P<0.05),且观察组舒张压(77.40±6.21)mmHg、收缩压(124.24±6.15)mmHg、心率(130.18±6.14)次/min,均比对照组的(93.47±7.40)mmHg、(140.60±7.48)mmHg、(150.35±12.32)次/min低(t=12.448、12.642、10.965,均P<0.05);观察组总不良反应率3.57%,比对照组的19.64%低(χ^2=7.049,P<0.05)。结论对快速型心律失常患者于急诊中应用胺碘酮治疗效果显著,能够稳定患者血压和心率,促进病情改善,且安全性较高,不良反应少。

Objective To analyze the efficacy and safety of amiodarone in the treatment of patients with tachyarrhythmia in emergency department. Methods The clinical data of 112 patients with emergency tachyarrhythmia admitted to the Emergency Department of the First People's Hospital of Jinzhong from March 2017 to March 2018 were analyzed.According to the different treatment plans applied, the patients were divided into two groups, with 56 patients in each group.The control group was given routine emergency treatment, and the observation group was treated with routine emergency treatment and amiodarone.The efficacy, blood pressure, heart rate and safety in the two groups were compared. Results The total effective rate in the observation group was 91.07%, which was higher than that in the control group(69.64%)(χ^2=8.145, P<0.05). The diastolic blood pressure, systolic blood pressure and heart rate in the observation group were (77.40±6.21)mmHg,(124.24±6.15)mmHg and (130.18±6.14)beats/min, respectively, which were lower than those in the control group[(93.47±7.40)mmHg,(140.60±7.48)mmHg and (150.35±12.32)bests/min](χ^2=8.145, t=12.448, 12.642, 10.966, all P<0.05). The total incidence rate of adverse reactions in the observation group was 3.57%, which was lower than 19.64% in the control group (χ^2=7.049, P<0.05). Conclusion For patients with tachyarrhythmia in the emergency department, the application of amiodarone has significant curative effects and high safety, which can help stabilize their blood pressure, heart rate and improve their conditions, and yet incurs less adverse reactions.Therefore, it is of significant value to be popularized in clinical applications.