头孢呋辛钠不同用药时间对妇产科手术患者手术切口感染及C反应蛋白的影响

Effects of different medication time of cefuroxime sodium on nosocomial infections of surgical incision and C-reactive protein in patients of Department of Obstetrics and Gynecology

目的探讨头孢呋辛钠不同用药时间对妇产科手术患者手术切口等医院感染及C反应蛋白的影响。方法选择沁县人民医院妇产科在2015年7月至2017年11月收治的158例手术患者,采用随机数字表方法分为观察组和对照组,每组79例。观察组在围手术期前后给予头孢呋辛钠治疗,对照组术后给予头孢呋辛钠治疗,比较不同用药时间选择对两组医院感染发生率及C反应蛋白的影响。结果观察组术后体温异常45例、体温恢复正常时间为(40.17±10.35)h,均少于对照组的59例、(56.35±9.87)h,两组差异均有统计学意义(χ^2=5.513,P=0.019;t=8.163,P=0.000)。观察组术后C反应蛋白为(2.34±0.66)mg/L、降钙素原为(2.48±0.79)mg/L,均优于对照组的(3.46±0.84)mg/L、(3.19±0.96)mg/L,两组差异均有统计学意义(t=9.260,P=0.000;t=5.104,P=0.000)。观察组术后出现切口感染2例,少于对照组术后出现切口感染9例,两组差异有统计学意义(χ^2=4.788,P=0.029)。观察组平均住院天数为(6.70±1.04)d,明显短于对照组的(8.26±1.25)d,两组差异有统计学意义(t=8.513,P=0.000)。术后观察组生活质量SF-36评分为(85.63±15.30)分,优于对照组的(71.29±11.07)分,两组差异有统计学意义(t=-6.748,P=0.000)。结论妇产科手术患者围手术期给予头孢呋辛钠可降低手术患者医院感染发生率、改善体内炎性水平因子,缩短住院时间以及提高患者生活质量。

Objective To study the effect of different medication time of cefuroxime sodium on nosocomial infections of surgical incision and C-reactive protein (CRP) in patients of Department of Obstetrics and Gynecology. Methods A total of 158 surgery patients in Department of Obstetrics and Gynecology who were treated in the People's Hospital of Qing County from July 2015 to November 2017 were enrolled in the study.According to random number method, they were randomly divided into control group and observation group, with 79 cases in each group.The observation group received the treatment of cefuroxime sodium in the perioperative period, the control group was given cefuroxime sodium treatment after surgery.The differences of the probability of a nosocomial infection and CRP between the two groups who chose different medication time were compared. Results The observation group had 45 patients appearing abnormal temperature after surgery, and the temperature restoring normal time was (40.17±10.35)h.The control group had 59 patients appearing abnormal temperature after surgery, and the temperature restoring normal time was (56.35±9.87)h, which of the observation group were less than that of the control group, the differences were statistically significant(χ^2=5.513, P=0.019;t=8.163, P=0.000). The levels of CRP and procalcitonin of the observation group after surgery were (2.34±0.66)mg/L,(2.48±0.79)mg/L, respectively, which were lower than those of the control group[(3.46±0.84)mg/L,(3.19±0.96)mg/L], the differences were statistically significant(t=9.260, P=0.000;t=5.104, P=0.000). The observation group had 2 patients appeared incision infection after surgery, the control group had 9 patients appeared incision infection after surgery, there was statistically significant difference between the two groups(χ^2=4.788, P=0.029). The hospitalization time of the observation group was (6.70±1.04)d, which was shorter than (8.26±1.25)d of the control group, there was statistically significant difference between the two groups(t=8.513, P=0.000). The quality of life score of the observation group after surgery was (85.63±15.30)points, which was higher than (71.29±11.07)points of the control group, there was statistically significant difference between the two groups(t=-6.748, P=0.000). Conclusion Using cefuroxime sodium in the perioperative period can reduce the probability of nosocomial infection in surgical patients, improve the level of inflammation in vivo, shorten the hospital stay and improve the quality of life of patients.