脂滴代谢与丙型肝炎病毒生活周期关联的研究进展

Progress in the study of the association between the lipid droplets and hepatitis C virus life cycle

脂滴(lipid droplets, LDs)是广泛存在的动态细胞器,它们在所有真核细胞和部分原核细胞中储存和供应脂质,用于能量代谢与脂膜合成等。越来越多的证据表明,丙型肝炎病毒(hepatitis C virus, HCV)由于自身缺乏脂质生物合成途径而发生了进化,使其能够利用宿主脂质代谢途径,建立适宜自身增殖的环境而获得必要的成分,最终促进病毒组装和运输。本文主要对HCV生活周期与脂滴生物合成及代谢之间的关联做一综述,以期为HCV引起的相关疾病及其治疗的研究提供线索。

Lipid droplets(LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis and production of essential lipid-derived molecules. There is increasing evidence that hepatitis C virus(HCV) has co-evolved due to its lack of lipid biosyn‐thetic pathways to utilize host lipid metabolic pathways to establish a suitable environment for virus proliferation and obtain the necessary components, eventually promote the assembly and transportation of virus. In this review,we outline the relationship between HCV life cycle and lipid droplet biosynthesis and metabolism, with the aim to discover potential antiviral targets for development of new therapeutic interventions.