颈动脉斑块稳定性超声评估与血浆脂蛋白相关磷脂酶A2水平的相关性研究

Correlation between stability of carotid plaque evaluated by ultrasound and the level of plasma Lp-PLA2

目的:探讨颈动脉粥样硬化斑块稳定性与血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平的相关性。方法:选择185例颈动脉粥样硬化患者作为研究对象,分为稳定斑块组(97例)和不稳定斑块组(88例),应用二维超声对所有斑块特征进行评估,所有对象均进行血浆Lp-PLA2检测。结果:不稳定斑块组血浆Lp-PLA2水平较高,与稳定斑块组间差异有统计学意义(P<0.05)。不稳定斑块的形态不规则、表面溃疡、偏心指数>2、斑块内部液化等特征均与血浆高Lp-PLA2有相关性(P<0.05)。血浆Lp-PLA2过高是影响颈动脉粥样硬化斑块稳定性的独立危险因素(P<0.05)。结论 :血浆Lp-PLA2水平与颈动脉粥样硬化斑块稳定性相关,Lp-PLA2过高是影响斑块稳定性的独立危险因素。

Objective: To evaluate the correlation between the stability of carotid plaques evaluated by ultrasound and the level of plasma lipoprotein-associated phospholipase A2(Lp-PLA2). Methods: One hundred and eighty-five patients with carotid plaque were divided into stable plaque group(97 cases) and unstable plaque group(88 cases). Two-dimensional ultra-sound were used to evaluate the characteristics of all the carotid plaque. Plasma Lp-PLA2 were detected for all the patients.Results: Compared to the stable plaque group, the level of Lp-PLA2 were higher in the unstable plaque group, there was a significant difference between them(P<0.05). The characteristics of stable plaque: irregular morphology, plaque ulceration, eccentricity index >2, liquefaction of the plaque are significantly associated with high plasma Lp-PLA2(P<0.05). High plasma LpPLA2 was an independent risk factor for instability of carotid plaques(P<0.05). Conclusion: The level of plasma Lp-PLA2 is correlated with the stability of carotid plaque. High plasma Lp-PLA2 is an independent risk factor for instability of carotid plaques(P<0.05).