摘要
介孔纳米二氧化硅作为抗肿瘤药物载体,在癌症治疗上的应用越来越受到关注。介孔纳米二氧化硅不仅可实现药物的有效递送,而且可显著提高药物的生物利用度。功能化介孔纳米二氧化硅还能提高药物对肿瘤细胞的靶向性,实现药物的特异性按需释放。该新型纳米载体在癌症治疗中具有非常广阔的应用前景。本文对介孔纳米二氧化硅作为药物载体在多种癌症治疗中的应用,以及不同表面修饰物对药物载体递送的影响和优势加以综述,并对功能化介孔纳米二氧化硅载体对提高药物抗癌活性和靶向性的积极作用提出了展望。
As a carrier of anti-tumor drugs, mesoporous nano-silica has attracted more and more attention in treating cancer. Mesoporous nano-silica can not only effectively deliver drugs, but also significantly improve the bioavailability of the drugs. Functionalized mesoporous nano-silica can also improve the targeting of drugs to tumor cells, leading to a drug-specific on-demand release. The new nanocarrier has a very broad application prospect in cancer therapy. In this paper, we review the application of mesoporous nano-silica as a drug carrier in the treatment of various cancers, and the effects and advantages of different surface modifiers on drug delivery. We also further envision the positive impacts of functionalized mesoporous nano-silica carriers on improving the anticancer activity and targeting of drugs.
作者
蔡幸美
商雨婷
王澈
CAI Xing-Mei;SHANG Yu-Ting;WANG Che(College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China;Key Laboratory of Biotechnology and Molecular Drug Development, Dalian 116081, Liaoning, China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2019年第3期274-279,共6页
Chinese Journal of Biochemistry and Molecular Biology
基金
2017年国家级和辽宁省大学生创新训练项目(No.201710165000031)
辽宁省教育厅重点室平台项目(No.L201683653)资助~~
关键词
介孔纳米二氧化硅
表面修饰
癌症
靶向性
药物载体
mesosorous silica nanoparticles ( MSNs )
surface modification
cancer
targeting
drug carrier
