基于“神经-内分泌-免疫网络”中药外治机制探讨

Mechanism of External Treatment with Traditional Chinese Medicine Based on "Neurological-Endocrine-Immune Network"

中药外用治疗疾病,不仅在外科,在急症、儿科、妇科、内科等方面均存在广泛的应用,且其疗效确切,存在使用方便、直达病灶,避免肝脏首过效应等优点。但其作用机制不清,影响其临床推广使用。本文基于中药外治临床应用,常用外治中药治病特点分析,外治常见疾病与"神经-内分泌-免疫网络"关系3个层面进行分析归纳,结果发现外治中药临床应用广泛,疗效确切;常用外治中药主治疾病发病机制与"神经-内分泌-免疫网络"密切关联,且对外治中药现代药理作用整理发现,其与"神经-内分泌-免疫网络"相关性达100%。通过对中药外治常见疾病与"神经-内分泌-免疫网络"关系分析发现,中药外用所治疾病发病机制与"神经-内分泌-免疫网络"密切相关。因而笔者认为"神经-内分泌-免疫网络"系统很可能是中药外治的主要作用机制之一。该机制的验证,在今后的研究中还需各科共同努力,进行临床或实验验证,为阐明中药外用机制提供参考,为中药外治推广应用提供依据。

With a clear efficacy in external treatment of diseases,traditional Chinese medicine(TCM)has been widely applied in surgery,in acute,pediatric,gynecological,internal medicine and other departments.Its advantages include easy use,direct access to lesions,and prevent of the first-pass effect of the liver.However,its mechanism of action is still unclear,which impacts its clinical promotion.This article makes analysis and summary on the clinical application of TCM in external treatment of diseases,the characteristics of commonly used TCM in treatment of diseases,and the relationship of the common externally treated diseases and the"neurologicalendocrine-immune network".The findings showed that TCM for external treatment were widely used,with exact curative effects;the pathogenesis of commonly used TCM for externally treating diseases is closely related to the"neuro-endocrine-immune network".Moreover,the modern pharmacological effects of TCM for externally treating diseases were found to be 100% related to the"neuro-endocrine-immune network".According to the analysis of the relationship between the common diseases externally treated with TCM and the"neuro-endocrine-immune network",the pathogenesis of the treatment with TCM is closely related to the"neuro-endocrine-immune network".Therefore,we believe that the"neuro-endocrine-immune network"system is probably one of the main mechanisms of action of TCMs for externally treating diseases.The verification of this mechanism requires the joint efforts of various departments in conducting clinical or experimental verification in the future,so as to provide a reference for clarifying the mechanism of TCM for external use,and basis for the promotion and application of TCM for external use.