创伤后应激障碍对血压、心率及心率变异性的影响

Effect of post-traumatic stress disorder on human blood pressure, heart rate, and heart rate variability

目的探讨创伤后应激障碍(PTSD)对血压、心率和心率变异性的影响。方法选择2016年5月-2018年1月空军第986医院和2018年2月-2018年5月解放军75600部队医院收治的PTSD患者78例作为研究组,以同期创伤后未发生应激障碍者72例作为对照组A,同期入院体检的健康人员74例作为对照组B,监测3组患者的血压、心率和心率变异性并进行组间比较。结果研究组收缩压和舒张压明显高于对照组A和对照组B,且对照组A明显高于对照组B,差异均有统计学意义(P<0.05)。研究组24h总心搏、平均心率、最快心率和最慢心率等指标均明显高于对照组A和对照组B(P<0.05),但对照组A与对照组B比较差异无统计学意义(P>0.05)。研究组SDNN、SDANN和SDNNindex显著低于对照组A和对照B,且对照组A显著低于对照组B,差异均有统计学意义(P<0.05),但两组rMSSD和PNN50比较差异无统计学意义(P>0.05)。结论 PTSD可导致血压升高、心率增快、自主神经张力异常及调节功能失衡。

Objective To investigate the effect of post-traumatic stress disorder posttraumatic stress disorder(PTSD on blood pressure, heart rate, and heart rate variability. Methods Seventy-eight patients with admitted in the 986 th Hospital of PLAAF(former the 323 th Hospital of PLA) from May 2016 to January 2018 and our hospital from February 2018 to May2018 were selected as the study group, and 72 patients with non stress disorder in the same period served as the control group A,and 74 healthy persons enrolled in the same period served as the control group B. The blood pressure, heart rate, and heart rate variability of the three groups were monitored and compared between the groups. Results The systolic and diastolic blood pressures of the patients in the study group were significantly higher than those in the control group A and control group B,and the control group A was significantly higher than the control group B(P<0.05). The 24 h total heart rate, average heart rate,fastest heart rate, and slowest heart rate of the patients in the study group were significantly higher than those of the control group A and control group B(P<0.05), but there was no significant difference between the control group A and control group B(P<0.05). The standard deviation of normal to normal intervals(SDNN), SDANN, and SDNN index of the patients in the study group were significantly lower than those of the control group A and control B, and the control group A was significantly lower than the control group B(P<0.05), however, there was no significant difference between the two groups in rMSSD and PNN50(P>0.05). Conclusion PTSD can raise blood pressure, increase heart rate, and lead to abnormal autonomic nervous tone and imbalance of regulatory function.