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高迁移率族蛋白B1和Toll样受体4在宫颈癌组织中的表达及相关性分析 被引量:4

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摘要 目的探讨高迁移率族蛋白B1 (HMGB1)、Toll样受体4 (TLR4)在宫颈癌组织中的表达及相关性,为临床诊治宫颈癌提供参考依据。方法采用免疫组织化学方法检测78例宫颈癌组织中HMGB1和TLR4的表达,分析两者表达的关系以及与宫颈癌的关系。结果相比于正常宫颈组织HMGB1表达量(9 121. 02±1 528. 67)和TLR4表达量(41 795. 94±756. 37),宫颈癌组织HMGB1表达量(61 744. 68±24 196. 95)和TLR4表达量(149 434. 89±41 083. 70)显著升高,差异有统计学意义(均P<0. 05);且宫颈癌组织HMGB1表达量和TLR4表达量呈正相关(rho=0. 781,P<0. 001)。结论在宫颈癌组织中HMGB1和TLR4表达量增高且呈正相关,随着宫颈癌临床分期、病理分级的升高,宫颈癌组织HMGB1和TLR4的表达增加。
出处 《中国妇幼保健》 CAS 2019年第6期1379-1382,共4页 Maternal and Child Health Care of China
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