摘要
为建立化妆品中乙二醇和二甘醇的气相色谱分析方法,采用DB-624色谱柱(30 m×0.53 mm×3μm),样品经甲醇超声提取后,用火焰离子化检测器(FID)检测,进样口温度250℃,检测器温度280℃,采用分流进样,分流比5︰1,进样量1μL,程序升温方式分离,外标法测定乙二醇和二甘醇的含量。结果发现,乙二醇和二甘醇在10~200mg/L范围内线性关系良好,相关系数分别为0.9992和0.9999。平均回收率分别为93.0%~101.2%和92.8%~101.3%,相对标准偏差(RSD)分别为0.60%~2.32%和0.86%~3.27%。该方法准确、可靠,可用于化妆品中乙二醇和二甘醇的检测。
To establish a method for determination of ethylene glycol and diethylene glycol in cosmetics by gas chromatography,the sample was extracted with methanol and then analyzed by gas chromatography coupled flame ionization detector with a DB-624 capillary column(30 m × 0.53 mm × 3 μm). The inlet temperature was 250 ℃ and the detector temperature was 280 ℃.The split sampling was applied with an optimized split ratio at 5/1 and the sample load was 1 μL. The components of interest were separated under a temperature program. The concentration of ethylene glycol and diethylene glycol in the sample were quanti?ed by external standard method. The results showed that a good linearity at the concentration range of 10 to 200 mg/L was obtained for both ethylene glycol and diethylene glycol with correlation coeficients of 0.9992 and 0.9999, respectively. The recoveries were 93.0% to 101.2% and 92.8% to 101.3%, the relative standard deviations(RSD) were 0.60% to 2.32% and 0.86%to 3.27% based on the concentration of components. The method is accurate and reliable, which can be applied to detect ethylene glycol and diethylene glycol in cosmetics.
作者
李莉
李硕
李祥胜
黑真真
曹进
LI Li;LI Shuo;LI Xiang-sheng;HEI Zhen-zhen;CAO Jin(National Institutes for Food and Drug Control,Beijing 100050,China;Anhui Institute for Food and Drug Control,Hefei 230051,Anhui,China)
出处
《香料香精化妆品》
CAS
2019年第1期42-46,共5页
Flavour Fragrance Cosmetics
关键词
化妆品
二甘醇
乙二醇
气相色谱法
cosmetics
diethylene glycol
ethylene glycol
gas chromatography