基于突触可塑性的疼痛研究及临床转化

Pain research and clinical transformation based on synaptic plasticity

疼痛是一种复杂的生理心理活动,常伴随各种疾病,由于其病因多样、发病机制复杂且尚不明确,而成为亟待解决的科学难题。文章主要阐述在疼痛发生过程中突触可塑性改变的研究进展、疼痛信号的转导与突触可塑性改变,以及突触结构可塑性、功能可塑性在疼痛中的作用,并对基于突触可塑性的疼痛治疗进行综述,旨在更好地认识疼痛机制并对其后续的治疗提供思路,以求为临床疼痛治疗提供更为可靠的证据。

Pain is a complicated physiological and psychological activity,which is always accompanied by various diseases.It has become an urgent problem to be solved because of its flexible etiology and complex mechanisms.This article mainly elaborates the progress of research on synaptic plasticity remodeling in pain,introduces the transduction and synaptic plasticity of pain signals,the role of synaptic structure and functional plasticity in pain,and review the treatment of pain based on synaptic plasticity.The aim of this review is to better understand the mechanism of pain,provides a novel idea for its subsequent treatment,and gives more reliable evidence for clinical pain treatment.