一氧化氮的心脏保护作用研究进展

Research progress in cardioprotective effects of nitric oxide

一氧化氮(nitric oxide,NO)作为体内重要的气体信号分子,对缺血/再灌注(ischemia/reperfusion,I/R)心脏具有重要的保护作用。NO通过环磷酸鸟苷酸(cyclic guanosine monophosphate,cGMP)依赖的蛋白激酶(cGMP-dependent protein kinase,PKG)以及蛋白质巯基(-SH)亚硝基化(S-亚硝基化)在心脏I/R过程中发挥保护作用。文章综述体内NO的合成及其在心脏I/R过程中的作用、NO的心脏保护机制、NO在临床心脏保护中的应用。为NO的心脏保护作用的进一步研究提供参考。

As an essential gaseous signal molecule,nitric oxide(NO)has an important role in cardioprotection after ischemia/reperfusion(I/R).To provide insights for further study of NO in cardioprotection,this article reviewed the research progress on NO synthesis,its role in cardiac I/R injury,cardioprotective mechanisms,and its clinical application.The cardioprotective effects of NO in cardiac I/R may produce via the cyclic guanosine monophosphate(cGMP)/cGMP-dependent protein kinase(PKG)signaling pathway and protein S-nitrosylation.The commonly used cardioprotective measures and drugs are dependent on NO to various extents.