摘要
利用金属离子的模板作用,以CaCl_2为交联剂,制备载天然抗癌药物齐墩果酸(OA)的叶酸-O-羧甲基壳聚糖(FA-O-CS)纳米粒子。采用核磁共振氢谱(~1HNMR)、红外光谱仪(FT-IR)和透射电子显微镜(TEM)检测结合物的结构,并对纳米粒子的形貌与大小进行表征。~1HNMR和FT-IR测试结果表明FA与O-CS成功联结。TEM观测到OA/FA-O-CS纳米粒子为球状,粒径均一,约为300nm。
The folic acid-O-carboxymethyl chitosan(FA-O-CS)nanoparticles containing the natural anticancer drug oleanolic acid(OA)were prepared by the template action of metal ions and CaCl2 as a crosslinking agent.The structure of the conjugate was detected by nuclear magnetic resonance spectroscopy(1HNMR),infrared spectroscopy(FT-IR),and transmission electron microscopy(TEM),and the morphology and size of the nanoparticles were characterized.The results of 1HNMR and FT-IR test confirmed that FA and O-CS were successfully connected.TEM observation showed that the OA/FA-O-CS nanoparticles were spherical and uniform in particle size,about 300 nm.
作者
崔翔瑞
苏崟
王英飒
刘六军
CUI Xiang-rui;SU Yin;WANG Ying-sa;LIU Liu-jun(Materials Science and Technology,Beijing Forestry University,Beijing 100083,China)
出处
《精细与专用化学品》
CAS
2019年第3期30-32,共3页
Fine and Specialty Chemicals
基金
北京林业大学2018年大学生科技创新创业训练计划项目(X201810022109)
