扁柏醇合成工艺研究

Synthesis process research of Hinokitiol

扁柏醇合成方法有很多,但大多不适合规模化生产。本研究采用环戊二烯和氢氧化钾为原料,经Wurtz取代反应、[2+2]环加成反应和Beckmann重排反应合成了高纯度扁柏醇。该方法反应步骤简单、原料易得、环境污染小,可制得纯度较高的扁柏醇,适合工业规模化生产。

There are many synthetic methods for Hinokitiol,but most of them are not suitable for large-scale production.Based on the ordinary chemical raw materials CPD(cyclopentadiene)and KOH as raw materials,by Wurtz substitution reaction,[2+2]cycloaddition and Beckmann rearrangement reaction of three step synthesis of high purity hinoki alcohol.The reaction step is simple,the raw materials are easy to obtain,and the environmental pollution is small,and the cedarol with high purity can be obtained,which is suitable for industrial scale.