四君子汤治疗脾气虚弱型老年性白内障的临床疗效

The Clinical Effect of Sijunzi Decoction in Treatment of Senile Cataract with Deficiency of Spleen-qi

目的:观察四君子汤对脾气虚弱型老年性白内障患者的临床疗效。方法:将符合纳入标准的脾气虚弱型老年性白内障患者60例120眼随机分为四君子汤组30例60眼和吡诺克辛组30例60眼,四君子汤组予四君子汤颗粒剂口服治疗,每次1包,150 ml温水冲泡,早晚饭后温服;吡诺克辛组予吡诺克辛钠滴眼液点眼,点双眼,每次1滴,3次/d,疗程均为3个月。比较治疗前和治疗3个月后患者的视力、晶状体混浊程度及中医证候疗效,以评定临床疗效。结果:两组患者治疗后最佳矫正视力均较治疗前有所提高,且治疗后四君子汤组最佳矫正视力较吡诺克辛组提高更显著(P<0.05);两组患者治疗后晶状体混浊程度均较治疗前减轻,且治疗后四君子汤组晶体混浊程度较吡诺克辛组减轻更显著(P<0.05)。两组患者治疗后中医证候疗效比较:吡诺克辛组显效0例,有效14例,无效16例,总有效率46.67%;四君子汤组显效13例,有效15例,无效2例,总有效率93.33%;两组中医证候疗效比较,差异具有统计学意义(P<0.05)。结论:四君子汤可提高脾气虚弱型老年性白内障患者最佳矫正视力,减轻患者的晶状体混浊程度,改善患者中医症候,对脾气虚弱型老年性白内障患者有一定的临床疗效,值得临床推广应用。

Objective: To observe the clinical effect of Sijunzi decoction in treatment of senile cataract with deficiency of spleen-qi.Methods: 120 Eyes of 60 senile cataract patients with deficiency of spleen-qi were divided into two groups randomly. The Sijunzi decoction group 60 eyes, was treated with oral Sijunzi decoction granules, 1 pack each time, twice a day. The Pirenoxine group 60 eyes,was treated with Pirenoxine eye drops, 3 times a day, the course of all treatment was 3 months. Before treatment and 3 months after treatment, the visual acuity, lens opacity and TCM syndromes were performed, the acquired index were statistic analyzed. Results: After treatment, the best corrected visual acuity and degree of lens opacity were improved in both groups, and the Sijunzi decoction group had more significant than that of the Pirenoxine group, and the differences were statistically significant(P <0.05). Comparison of TCM syndromes: in Pirenoxine group, 0 case of marked effect, 14 cases of effective, 16 cases of ineffective, and 46.67% of effective rate;in Sijunzi decoction group, 13 cases of marked effect, 15 cases of effective and 2 cases of ineffective. The difference of the two groups was statistically significant(P<0.05). Conclusion: Sijunzi decoction can improve the best corrected visual acuity and the symptoms of TCM of senile cataract with deficiency of spleen-qi, reduce the degree of lens opacity, and have certain clinical curative effect. It is worth popularizing and applying in clinic.