丹参酮ⅡA磺酸钠联合阿托伐他汀钙对冠心病心力衰竭的影响

Effects of Sodium TanshinonⅡA Silate Joined with Atorvastatin on Coronary Heart Disease Heart Failure

目的:观察丹参酮ⅡA磺酸钠联合阿托伐他汀治疗冠心病心力衰竭的临床疗效。方法:将64例冠心病心力衰竭患者随机分为对照组和观察组,各32例,对照组予阿托伐他汀钙,10 mg/次,1次/d;观察组在对照组的基础上给予丹参酮ⅡA磺酸钠注射液80mg+5%葡萄糖注射液250m L静脉滴注,1次/d。2组均于治疗4周后,观察临床疗效、不良反应及治疗前后心功能、氧化应激、血管活性物质水平的变化情况。结果:总有效率观察组为87.50%,对照组为62.50%,2组比较差异有统计学意义(P<0.05)。每分钟排血量(CO)、心脏指数(CI)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDd)、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、血管内皮生长因子(VEGF)、内皮素1(ET-1)、血管性血友病因子(VWF)等指标治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。不良反应发生率观察组为6.25%,对照组为12.50%,2组比较差异无统计学意义(P>0.05)。结论:丹参酮ⅡA磺酸钠联合阿托伐他汀钙治疗冠心病心力衰竭患者临床疗效显著,安全性高,可改善心功能,这可能与抑制氧化应激反应、改善血管内皮功能有关。

Objective:To observe clinical effects of sodium tanshinonⅡA silate joined with atorvastatin in treating coronary heart disease heart failure.Methods:All 64 patients were randomly allocated to the control group and the observation group,32 cases each group,the control group were treated by atorvastatin,10 mg each time,once each day;the observation group received intravenous dripping of sodium tanshinonⅡA silate injection,80 mg and 5%dextrose injection,250mL,once each day,on the foundation of the therapy the control group accepted.The levels of vaso-active substance,oxidative stress,heart function before and after treating,adverse reaction and clinical effects of both groups were observed after they were treated for four weeks.Results:Total effective rate of the observation group was 87.50%,higher than 62.50%of the control group,and the difference was statistically significant(P<0.05).The difference had statistical meaning in the comparisons of cardiac output(CO),cardiac index(CI),left ventricular ejection fraction(LVEF),left ventricular end diastolic dimension(LVEDd),SOD,MDA,NO,VEGF,ET-1 and VWF within two groups before and after treating(P<0.05);the difference had statistical meaning in the comparisons between both groups after treating(P<0.05).The incidence of adverse reaction of the observation group was 6.25%,lower than 12.50%of the control group,and the difference had no statistical meaning(P>0.05).Conclusion:Sodium tanshinonⅡA silate joined with atorvastatin is effective in treating coronary heart disease heart failure with high safety,which could improve cardiac function,and this might be related to inhibiting oxidative stress reaction and improving vascular endothelial function.