黄连素治疗2型糖尿病及其并发症作用机制研究进展

Research Progress of the Mechanism of Berberine in the Treatment of Type 2 Diabetes Mellitus and Complications

黄连素(berberine,BBR)主要是从传统中药黄连中分离出来的异喹啉生物碱。现代药理学研究表明,黄连素具有明显的抗氧化,抗炎,降糖和降脂等功效,在2型糖尿病及其引起的心、脑、肾等靶器官损害性疾病及代谢相关的肥胖症方面发挥显著优势。该篇文章主要对近5年来关于黄连素对2型糖尿病及其并发症机制的研究进展进行综述,从而为黄连素在临床的广泛应用提供依据。

Berberine (BBR) is mainly an isoquinoline alkaloid isolated from the traditional Chinese medicine Coptidis Rhizoma. Modern pharmacological research shows, berberine has obvious anti-oxidation, anti-inflammatory, hypoglycemic and lipid-lowering effects, and plays a significant advantage in type 2 diabetes mellitus and its target organ damage diseases such as heart, brain and kidney, and metabolism-related obesity. This article reviews the research progress of berberine on type 2 diabetes mellitus and its complications in the past five years, Thereby providing a basis for the extensive clinical application of berberine.