Grb7和PMS2在肺腺癌的表达及其临床意义

Expression and clinical significance of Grb7 and PMS2 in lung adenocarcinoma

目的探讨生长因子受体结合蛋白7(Grb7)和减数分裂后分离增强蛋白2(PMS2)在肺腺癌组织中的表达及其临床意义。方法采用免疫组化法检测102例肺腺癌组织及其癌旁组织中Grb7和PMS2的表达,分析其与临床特征的关系。结果 Grb7和PMS2在肺腺癌组织中的阳性率均高于癌旁组织(96.1%vs.8.8%和68.6%vs.8.8%)(P<0.05)。Grb7和PMS2表达与肺腺癌患者的性别、年龄、吸烟史及5年生存状态均不存在相关关系(P>0.05);但Grb7表达与TNM分期密切相关(P<0.05)。Grb7与PMS2在肺腺癌组织中的表达亦不存在相关关系(P>0.05)。结论Grb7的高表达与肺腺癌的TNM分期、侵袭和转移相关,可作为评估肺腺癌患者预后的相关指标。

Objective To investigate the expression and clinical significance of growth factor receptor bound protein 7(Grb7)and postmeiotic segregation increased 2(PMS2)in lung adenocarcinoma. Methods The expressions of Grb7 and PMS2 were detected by immunohistochemistry assay in 102 cases of lung adenocarcinoma tissues and corresponding tumoradjacent tissues.Then the correlation between the expressions and clinicopathologic characteristics was analyzed.Results The positive expression rates of Grb7 and PMS2 in the lung adenocarcinoma tissues were higher than those in the tumor-adjacent tissues(96.1% vs.8.8% and 68.6% vs.8.8%)(P<0.05).The expressions of Grb7 and PMS2 were not closely related to sex,age,smoking history and 5-year survival rate(P>0.05),but Grb2 expression was closely correlated with TNM stage in the patients with lung adenocarcinoma(P<0.05).Moreover,there was no significant correlation between the expressions of Grb7 and PMS2 in the lung adenocarcinoma tissues(P>0.05).Conclusion The higher expression of Grb7 has a close correlation with the lower TNM stage,invasion and metastasis of lung adenocarcinoma and may serve as a new indicator for evaluating the prognosis of the patients with lung adenocarcinoma.