正常成人胼胝体膝部及压部弥散张量成像分析

An analysis of diffusion tensor imaging of genu and splenium in adult corpus callosum

目的分析正常成人胼胝体膝部及压部弥散张量成像(DTI)指标变化。方法测量40例正常成年人胼胝体膝部及压部的正中矢状位DTI图像部分各向异性分数(FA),计算表观弥散系数(ADC),分析不同性别和年龄的FA和ADC值差异。结果胼胝体膝部及压部FA和ADC值无性别差异(P>0.05),但其年龄差异有统计学意义(P<0.05或P<0.01)。正常成人胼胝体膝部及压部FA值与年龄呈负相关(R^2=0.313,P<0.01及R^2=0.098,P<0.05),ADC值与年龄呈正相关(R^2=0.115,P<0.05及R^2=0.304,P<0.01)。结论正常成人胼胝体膝部及压部FA值与年龄呈负相关,而ADC值与年龄呈正相关。

Objective To analyze the changes and gender and age differences of diffusion tensor imaging(DTI)in genu and splenium of adult corpus callosum.Methods The values of fractional anisotraphy(FA)and apparent diffusion coefficient(ADC)in images of DTI of genu and splenium of the corpus callosum at median sagittal position were obtained.The age and gender differences of FA and ADC were analyzed.Results Values of FA and ADC in genu and splenium of the corpus callosum were not significantly different between male and female adults(P>0.05),which were significantly different among different age groups(P<0.05 or P<0.01).FA value of genu and splenium of the corpus callosum in normal adults was negatively correlated to age(R^2=0.313,P<0.01 and R^2=0.098,P<0.05),while ADC value of which was positively correlated to age(R^2=0.115,P<0.05 and R^2=0.304,P<0.01).Conclusion FA value of genu and splenium of the corpus callosum is negatively correlated with age,but ADC value of which is positively correlated with age.